Fluoroindolocarbazole A
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| Category | Antibiotics |
| Catalog number | BBF-01418 |
| CAS | |
| Molecular Weight | 537.47 |
| Molecular Formula | C27H21F2N3O7 |
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Description
Fluoroindolocarbazole A is produced by the strain of Saccharothrothrix aerocolonigenes. Fluoroindolocarbazole A has antitumor effect.
Specification
| IUPAC Name | 3-[(2R,3R,4R,5S,6R)-3,4-dihydroxy-6-(hydroxymethyl)-5-methoxyoxan-2-yl]-6,20-difluoro-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione |
| Canonical SMILES | COC1C(OC(C(C1O)O)N2C3=C(C=CC(=C3)F)C4=C5C(=C6C7=C(C=C(C=C7)F)NC6=C42)C(=O)NC5=O)CO |
| InChI | InChI=1S/C27H21F2N3O7/c1-38-24-15(8-33)39-27(23(35)22(24)34)32-14-7-10(29)3-5-12(14)17-19-18(25(36)31-26(19)37)16-11-4-2-9(28)6-13(11)30-20(16)21(17)32/h2-7,15,22-24,27,30,33-35H,8H2,1H3,(H,31,36,37)/t15-,22-,23-,24-,27-/m1/s1 |
| InChI Key | HASPDWQMLDEIPM-HHJYCPGKSA-N |
Properties
| Appearance | Light Yellow Solid |
| Antibiotic Activity Spectrum | neoplastics (Tumor) |
Reference Reading
1. Production, isolation and structure determination of novel fluoroindolocarbazoles from Saccharothrix aerocolonigenes ATCC 39243
K S Lam, D R Schroeder, J M Veitch, K L Colson, J A Matson, W C Rose, T W Doyle, S Forenza J Antibiot (Tokyo). 2001 Jan;54(1):1-9. doi: 10.7164/antibiotics.54.1.
Saccharothrix aerocolonigenes ATCC 39243 produces an indolocarbazole antitumor agent rebeccamycin under submerged fermentation conditions. Adding DL-6-fluorotryptophan to culture of S. aerocolonigenes ATCC 39243 induces the formation of two novel indolocarbazoles, fluoroindolocarbazoles A and B. Feeding DL-5-fluorotryptophan to culture of S. aerocolonigenes ATCC 39243 induces the production of a novel indolocarbazole, fluoroindolocarbazole C. These fluoroindolocarbazoles have been isolated from culture broth and purified to homogeneity by vacuum liquid chromatography and column chromatography. All three fluoroindolocarbazoles are more potent than rebeccamycin against P388 leukemia by ip route in murine model.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
