Fluvirucin B1
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| Category | Antibiotics |
| Catalog number | BBF-01426 |
| CAS | 137428-64-9 |
| Molecular Weight | 442.64 |
| Molecular Formula | C24H46N2O5 |
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Description
Fluvirucin B1 is produced by Actinomycete R359-5. It has the activity against influenza virus.
Specification
| IUPAC Name | 10-[(2R,3R,4R,5S,6S)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy-3,11-diethyl-7-methyl-azacyclotetradecan-2-one |
| Canonical SMILES | CCC1CCCNC(=O)C(CCCC(CCC1OC2C(C(C(C(O2)C)O)N)O)C)CC |
| InChI | InChI=1S/C24H46N2O5/c1-5-17-11-8-14-26-23(29)18(6-2)10-7-9-15(3)12-13-19(17)31-24-22(28)20(25)21(27)16(4)30-24/h15-22,24,27-28H,5-14,25H2,1-4H3,(H,26,29)/t15?,16-,17?,18?,19?,20+,21+,22+,24-/m0/s1 |
| InChI Key | MJDWUOZLTDXLJL-KFKPSDQKSA-N |
Properties
| Appearance | Colorless Acicular Crystalline |
| Antibiotic Activity Spectrum | viruses |
| Melting Point | 262-263°C |
Reference Reading
1. Sequence, cloning, and analysis of the fluvirucin B1 polyketide synthase from Actinomadura vulgaris
Tsung-Yi Lin, Lawrence S Borketey, Gitanjeli Prasad, Stephanie A Waters, Nathan A Schnarr ACS Synth Biol. 2013 Nov 15;2(11):635-42. doi: 10.1021/sb4000355. Epub 2013 Apr 16.
Fluvirucin B1 , produced by Actinomadura vulgaris, is a 14-membered macrolactam active against a variety of infectious fungi as well as influenza A. Despite considerable interest from the synthetic community, very little information is available regarding the biosynthetic origins of the fluvirucins. Herein, we report the identification and initial characterization of the fluvirucin B1 polyketide synthase and related enzymes. The cluster consists of five extender modules flanked by an N-terminal acyl carrier protein and C-terminal thioesterase domain. All but one of the synthase modules contain the full complement of tailoring domains (ketoreductase, dehydratase, and enoyl reductase) as determined by sequence homology with known polyketide synthases. Acitve site analyses of several key components of the cluster are performed to further verify that this gene cluster is associated with production of fluvirucin B1 . This work will both open doors toward a better understanding of macrolactam formation and provide an avenue to genetics-based diversification of fluvirucin structure.
2. Anthelmintic macrolactams from Nonomuraea turkmeniaca MA7381
Sloan Ayers, Deborah L Zink, Joanne Staats Powell, Christine M Brown, Alan Grund, Olga Genilloud, Oscar Salazar, Donald Thompson, Sheo B Singh J Antibiot (Tokyo). 2008 Feb;61(2):59-62. doi: 10.1038/ja.2008.110.
A new macrolactam, fluvirucin B0 (1), and two known macrolactams, Sch 38516/fluvirucin B1 (2) and Sch 39185/fluvirucin B3 (3), have been isolated from an acetone extract of a strain of Nonomuraea turkmeniaca. These compounds were isolated by bioassay-guided fractionation as part of our search for new anthelmintics. The structures of these compounds were elucidated by comparison of their NMR and MS data to those of previously reported fluvirucins, and confirmed by 2D-NMR. 1approximately 3 exhibited in vitro activity (EC90 <1.0 approximately 1.7 microg/ml) against Haemonchus contortus larvae, but were ineffective in reducing worm counts in vivo against Heligmosomoides polygyrus in mice at 50 mg/kg dosed intramuscularly.
3. Enantioselective Total Synthesis of Fluvirucinin B1
Guillaume Guignard, Núria Llor, Elies Molins, Joan Bosch, Mercedes Amat Org Lett. 2016 Apr 15;18(8):1788-91. doi: 10.1021/acs.orglett.6b00513. Epub 2016 Apr 5.
A convergent synthesis of fluvirucinin B1 from acid ent-6a and nitrile ent-9, involving an organocopper coupling, a stereoselective allylation, a ring-closing metathesis reaction, and a stereoselective hydrogenation as the key steps, is reported. The starting building blocks have been prepared in a straightforward manner from a common phenylglycinol-derived lactam 1. An unprecedented regioselective oxidation of phenylglycinol-derived secondary amines 5 to carboxylic acids 6 has been developed.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
