Folic acid
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| Category | Raw Materials of Healthcare Products |
| Catalog number | BBF-04029 |
| CAS | 59-30-3 |
| Molecular Weight | 441.40 |
| Molecular Formula | C19H19N7O6 |
| Purity | >98% |
Ordering Information
| Catalog Number | Size | Price | Stock | Quantity |
|---|---|---|---|---|
| BBF-04029 | 500 g | $199 | In stock |
Online Inquiry
Add to cartDescription
Folic acid is a vitamin needed to synthesize DNA, conduct DNA repair and methylate DNA, and it also acts as a cofactor in biological reactions involving folate. The combined use of enalapril and folic acid, compared with enalapril alone, significantly reduced the risk of first stroke. High folic acid intakes and MTHFR gene variations seem not to be associated with helping women to achieve pregnancy during or after fertility treatment.
Specification
| Synonyms | n-4-[(2-amido-4-oxo-1,4-dihydro-6-terene)methylamino]benzoyl-l-glutamic acid |
| Shelf Life | As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly |
| Storage | Store at -20°C |
| IUPAC Name | (2S)-2-[[4-[(2-amino-4-oxo-3H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid |
| Canonical SMILES | C1=CC(=CC=C1C(=O)NC(CCC(=O)O)C(=O)O)NCC2=CN=C3C(=N2)C(=O)N=C(N3)N |
| InChI | InChI=1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1 |
| InChI Key | OVBPIULPVIDEAO-LBPRGKRZSA-N |
Properties
| Appearance | Yellow Powder |
| Application | Hematopoietic vitamin |
| Melting Point | >195°C |
| Density | 1.68 g/cm3 |
| Solubility | Soluble in DMSO |
| LogP | -2.5 |
Toxicity
| Carcinogenicity | No indication of carcinogenicity to humans (not listed by IARC). |
| Mechanism Of Toxicity | Folic acid, as it is biochemically inactive, is converted to tetrahydrofolic acid and methyltetrahydrofolate by dihydrofolate reductase. These folic acid congeners are transported across cells by receptor-mediated endocytosis where they are needed to maintain normal erythropoiesis, synthesize purine and thymidylate nucleic acids, interconvert amino acids, methylate tRNA, and generate and use formate. Using vitamin B12 as a cofactor, folic acid can normalize high homocysteine levels by remethylation of homocysteine to methionine via methionine synthetase. |
| Toxicity | LD50: 85 mg/kg (Intraperitoneal, Mouse); LD50: 120 mg/kg (Intravenous, Guinea pig); LD50: 239 mg/kg (Intravenous Mouse); LD50: 500 mg/kg (Intravenous, Rat); LD50: 410 mg/kg (Intravenous, Rabbit). |
Reference Reading
1.Impact of Laboratory Test Use Strategies in a Turkish Hospital.
Yılmaz FM1, Kahveci R2, Aksoy A3, Özer Kucuk E2, Akın T4, Mathew JL5, Meads C6, Zengin N7. PLoS One. 2016 Apr 14;11(4):e0153693. doi: 10.1371/journal.pone.0153693. eCollection 2016.
OBJECTIVES: Eliminating unnecessary laboratory tests is a good way to reduce costs while maintain patient safety. The aim of this study was to define and process strategies to rationalize laboratory use in Ankara Numune Training and Research Hospital (ANH) and calculate potential savings in costs.
2.Prevalence of anaemia and associated risk factors among pregnant women attending antenatal care in Gulu and Hoima Regional Hospitals in Uganda: A cross sectional study.
Obai G1, Odongo P2, Wanyama R3. BMC Pregnancy Childbirth. 2016 Apr 11;16(1):76. doi: 10.1186/s12884-016-0865-4.
BACKGROUND: Anaemia is a public health problem affecting over 1.62 billion people globally. It affects all age groups of people and is particularly more prevalent in pregnant women. Africa carries a high burden of anaemia; in Uganda 24 % of women of child bearing age have anaemia. Pregnant women living in poverty are at greater risk of developing iron deficiency anaemia. The objective of this study was to determine the prevalence of anaemia and the associated risk factors in pregnant women attending antenatal care at Gulu and Hoima Regional Hospitals in Northern and Western Uganda respectively.
3.Fluorescence "turn-on" determination of H2O2 using multilayer porous SiO2/NGQDs and PdAu mimetics enzymatic/oxidative cleavage of single-stranded DNA.
Liang L1, Lan F1, Li L1, Su M1, Ge S2, Yu J1, Liu H1, Yan M1. Biosens Bioelectron. 2016 Apr 1;82:204-211. doi: 10.1016/j.bios.2016.03.076. [Epub ahead of print]
A 3D microfluidic paper-based fluorescence analytical device with hollow channels based on the turn-on switching of a resonance energy transfer triggered by the •OH induced cleavage of a DNA strand was successfully constructed. And this fluorescent nanoplatform was first designed to achieve in situ and real-time determination of H2O2 released from cancer cells to obtain an accurate determination. With optimal conditions, the proposed method displayed excellent analytical performance for the detection of H2O2 ranging from 0.3 to 1.0mM with a detection limit of 0.1nM. The favorable performances of this sensor were due to the peroxidase-like activity of nitrogen-doped graphene quantum dots (multilayer porous SiO2 act as stabilizer to load more nitrogen-doped graphene quantum dots for signal amplification) and folic acid-pPdAu/GO (which also could act as an efficient fluorescence quencher and a recognition element of cancer cells by folic acid).
4.Low Serum Vitamin B-12 Concentrations Are Prevalent in a Cohort of Pregnant Canadian Women.
Visentin CE1, Masih SP1, Plumptre L1, Schroder TH2, Sohn KJ3, Ly A4, Lausman AY5, Berger H5, Croxford R6, Lamers Y2, Kim YI7, O'Connor DL8. J Nutr. 2016 Apr 13. pii: jn226845. [Epub ahead of print]
BACKGROUND: Among Canadian women of reproductive age, 5% and 20% have serum vitamin B-12 concentrations indicative of deficiency (<148 pmol/L) and marginal status (148-220 pmol/L), respectively. Given the association between suboptimal vitamin B-12 and adverse pregnancy outcomes, an understanding of vitamin B-12 status during pregnancy, and factors that influence it, is required.
Spectrum
Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive
Experimental Conditions
Ionization Mode: Positive
Ionization Energy: 70 eV
Chromatography Type: Gas Chromatography Column (GC)
Instrument Type: Single quadrupole, spectrum predicted by CFM-ID(EI)
Mass Resolution: 0.0001 Da
Molecular Formula: C19H19N7O6
Molecular Weight (Monoisotopic Mass): 441.1397 Da
Molecular Weight (Avergae Mass): 441.3975 Da
Ionization Energy: 70 eV
Chromatography Type: Gas Chromatography Column (GC)
Instrument Type: Single quadrupole, spectrum predicted by CFM-ID(EI)
Mass Resolution: 0.0001 Da
Molecular Formula: C19H19N7O6
Molecular Weight (Monoisotopic Mass): 441.1397 Da
Molecular Weight (Avergae Mass): 441.3975 Da
LC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)
Experimental Conditions
Sample Concentration: 1.0 mM
Sample Mass: 1.0 mg
Sample Assessment: Satisfactory
Spectrum Assessment: Satisfactory
Instrument Type: Quattro_QQQ
Collision Energy Level: low
Collision Energy Voltage: 10
Ionization Mode: Positive
Sample Mass: 1.0 mg
Sample Assessment: Satisfactory
Spectrum Assessment: Satisfactory
Instrument Type: Quattro_QQQ
Collision Energy Level: low
Collision Energy Voltage: 10
Ionization Mode: Positive
Predicted LC-MS/MS Spectrum - 10V, Positive
Experimental Conditions
Ionization Mode: Positive
Collision Energy: 10 eV
Instrument Type: QTOF (generic), spectrum predicted by CFM-ID
Mass Resolution: 0.0001 Da
Molecular Formula: C19H19N7O6
Molecular Weight (Monoisotopic Mass): 441.1397 Da
Molecular Weight (Avergae Mass): 441.3975 Da
Collision Energy: 10 eV
Instrument Type: QTOF (generic), spectrum predicted by CFM-ID
Mass Resolution: 0.0001 Da
Molecular Formula: C19H19N7O6
Molecular Weight (Monoisotopic Mass): 441.1397 Da
Molecular Weight (Avergae Mass): 441.3975 Da
Mass Spectrum (Electron Ionization)
1H NMR Spectrum
Experimental Conditions
Solvent: Water
Sample Assessment: Excellent
Spectrum Assessment: Excellent
Instrument Type: Varian
Nucleus: 1H
Frequency: 500 MHz
Sample pH: 7.00
Sample Temperature: 25.0 Celsius
Chemical Shift Reference: DSS
Sample Assessment: Excellent
Spectrum Assessment: Excellent
Instrument Type: Varian
Nucleus: 1H
Frequency: 500 MHz
Sample pH: 7.00
Sample Temperature: 25.0 Celsius
Chemical Shift Reference: DSS
[1H,13C] 2D NMR Spectrum
Experimental Conditions
Sample Concentration: 50.0 mM
Solvent: Water
Sample Mass: 22.1 mg
Sample Assessment: Excellent
Spectrum Assessment: Excellent
Instrument Type: Bruker
Nucleus X: 1H
Nucleus Y: 13C
Frequency: 600 MHz
Sample pH: 7.00
Sample Temperature: 25.0 Celsius
Chemical Shift Reference: DSS
Solvent: Water
Sample Mass: 22.1 mg
Sample Assessment: Excellent
Spectrum Assessment: Excellent
Instrument Type: Bruker
Nucleus X: 1H
Nucleus Y: 13C
Frequency: 600 MHz
Sample pH: 7.00
Sample Temperature: 25.0 Celsius
Chemical Shift Reference: DSS
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
