Folipastatin
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| Category | Enzyme inhibitors |
| Catalog number | BBF-01844 |
| CAS | 139959-71-0 |
| Molecular Weight | 380.43 |
| Molecular Formula | C23H24O5 |
| Purity | ≥95% |
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Description
Folipastatin is a fungal metabolite that is produced by A. unguis. Folipastatin is also an inhibitor of phospholipase A2 (PLA2) with an IC50 of 39 μM.
Specification
| Synonyms | 3,8-dihydroxy-4,9-dimethyl-1,6-bis[(1Z)-1-methyl-1-propen-1-yl]-11H-dibenzo[b,e][1,4]dioxepin-11-one; E323392EAO |
| Storage | -20°C |
| IUPAC Name | 1,7-bis[(Z)-but-2-en-2-yl]-3,9-dihydroxy-4,10-dimethylbenzo[b][1,4]benzodioxepin-6-one |
| Canonical SMILES | CC=C(C)C1=CC(=C(C2=C1C(=O)OC3=C(O2)C(=CC(=C3C)O)C(=CC)C)C)O |
| InChI | InChI=1S/C23H24O5/c1-7-11(3)15-9-17(24)13(5)20-19(15)23(26)28-21-14(6)18(25)10-16(12(4)8-2)22(21)27-20/h7-10,24-25H,1-6H3/b11-7-,12-8- |
| InChI Key | JJMKBGPTPXPMBH-OXAWKVHCSA-N |
Properties
| Appearance | Colorless Acicular Crystalline |
| Boiling Point | 588.3°C at 760 mmHg |
| Melting Point | 246-248°C |
| Density | 1.213 g/cm3 |
| Solubility | Soluble in DMSO |
Reference Reading
1. Folipastatin, a new depsidone compound from Aspergillus unguis as an inhibitor of phospholipase A2. Taxonomy, fermentation, isolation, structure determination and biological properties
M Kinoshita-Okami, T Hosoya, K Hamano, M Hisamoto, A Sato, K Tanzawa, K Yoda, H Haruyama, K Matsuda, A Hemmi J Antibiot (Tokyo) . 1992 Aug;45(8):1195-201. doi: 10.7164/antibiotics.45.1195.
A new inhibitor of phospholipase A2 was isolated from the fermentation broth of Aspergillus unguis. The structure, with a depsidone carbon skeleton, was assigned by spectroscopic experiments.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
