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Folipastatin

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Folipastatin
Category Enzyme inhibitors
Catalog number BBF-01844
CAS 139959-71-0
Molecular Weight 380.43
Molecular Formula C23H24O5
Purity ≥95%

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Capabilities & Facilities

Fermentation Lab

4 R&D and scale-up labs

2 Preparative purification labs

Fermentation Plant

Semi pilot, pilot and industrial plant 4 Manufacturing sites 7 Production lines at pilot scale 100+ Reactors of 30-4000 L; 170+ reactors of 20 KL-30 KL; 24+ reactors of >100 KL 2 Hydrogenation reactors (200 L, 4Mpa and 1000L, 4Mpa)

Product Description

Folipastatin is a fungal metabolite that is produced by A. unguis. Folipastatin is also an inhibitor of phospholipase A2 (PLA2) with an IC50 of 39 μM.

  • Specification
  • Properties
  • Reference Reading
  • Price Product List
Synonyms 3,8-dihydroxy-4,9-dimethyl-1,6-bis[(1Z)-1-methyl-1-propen-1-yl]-11H-dibenzo[b,e][1,4]dioxepin-11-one; E323392EAO
Storage -20°C
IUPAC Name 1,7-bis[(Z)-but-2-en-2-yl]-3,9-dihydroxy-4,10-dimethylbenzo[b][1,4]benzodioxepin-6-one
Canonical SMILES CC=C(C)C1=CC(=C(C2=C1C(=O)OC3=C(O2)C(=CC(=C3C)O)C(=CC)C)C)O
InChI InChI=1S/C23H24O5/c1-7-11(3)15-9-17(24)13(5)20-19(15)23(26)28-21-14(6)18(25)10-16(12(4)8-2)22(21)27-20/h7-10,24-25H,1-6H3/b11-7-,12-8-
InChI Key JJMKBGPTPXPMBH-OXAWKVHCSA-N
Appearance Colorless Acicular Crystalline
Boiling Point 588.3°C at 760 mmHg
Melting Point 246-248°C
Density 1.213 g/cm3
Solubility Soluble in DMSO
1. Folipastatin, a new depsidone compound from Aspergillus unguis as an inhibitor of phospholipase A2. Taxonomy, fermentation, isolation, structure determination and biological properties
M Kinoshita-Okami, T Hosoya, K Hamano, M Hisamoto, A Sato, K Tanzawa, K Yoda, H Haruyama, K Matsuda, A Hemmi J Antibiot (Tokyo) . 1992 Aug;45(8):1195-201. doi: 10.7164/antibiotics.45.1195.
A new inhibitor of phospholipase A2 was isolated from the fermentation broth of Aspergillus unguis. The structure, with a depsidone carbon skeleton, was assigned by spectroscopic experiments.
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Tip: Chemical formula is case sensitive. C22H30N4O c22h30n40
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