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Forskolin

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Forskolin
Category Others
Catalog number BBF-05802
CAS 66575-29-9
Molecular Weight 410.50
Molecular Formula C22H34O7
Purity ≥98%
Catalog Number Size Price Stock Quantity
BBF-05802 100 mg $298 In stock

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Fermentation Lab

4 R&D and scale-up labs

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Semi pilot, pilot and industrial plant 4 Manufacturing sites 7 Production lines at pilot scale 100+ Reactors of 30-4000 L; 170+ reactors of 20 KL-30 KL; 24+ reactors of >100 KL 2 Hydrogenation reactors (200 L, 4Mpa and 1000L, 4Mpa)

Product Description

Forskolin is a naturally occurring diterpene that is produced by the Indian Coleus plant. It directly activates adenylyl cyclase through its catalytic subunit and is commonly used to raise levels of cAMP in a wide variety of intact cells and tissue preparations.

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Related CAS 66428-89-5
Synonyms Coleonol; HL 362; L 75-1362B; NSC 357088; NSC 375489; (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(Acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1H-Naphtho[2,1-b]pyran-1-one; (-)-Forskolin; Colforsin; ForsLean
Storage Store at -20°C
IUPAC Name [(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-5,6,6a,8,9,10-hexahydro-2H-benzo[f]chromen-5-yl] acetate
Canonical SMILES CC(=O)OC1C(C2C(CCC(C2(C3(C1(OC(CC3=O)(C)C=C)C)O)C)O)(C)C)O
InChI InChI=1S/C22H34O7/c1-8-19(5)11-14(25)22(27)20(6)13(24)9-10-18(3,4)16(20)15(26)17(28-12(2)23)21(22,7)29-19/h8,13,15-17,24,26-27H,1,9-11H2,2-7H3/t13-,15-,16-,17-,19-,20-,21+,22-/m0/s1
InChI Key OHCQJHSOBUTRHG-KGGHGJDLSA-N
Appearance White Solid
Boiling Point 519.9±50.0°C at 760 mmHg
Melting Point 220-230°C
Density 1.2±0.1 g/cm3
Solubility Soluble in Chloroform (Slightly), Methanol (Slightly)
1.Establishment and Characterization of Naïve Pluripotency in Human Embryonic Stem Cells.
Warrier S1, Popovic M1, Van der Jeught M1, Heindryckx B2. Methods Mol Biol. 2016 Apr 5. [Epub ahead of print]
Mouse embryonic stem cells are known to represent the naïve state of pluripotency, while human embryonic stem cells typically represented the primed state of pluripotency, characterized by a higher drift toward differentiation and some other disadvantages. Here we describe an efficient method for rapid, transgene free induction of the naïve pluripotent state in human by applying a novel combination of small molecules and growth factors in the culture medium (2i, LIF, basic fibroblast growth factor, ascorbic acid, and forskolin). Conversion of primed human embryonic stem cells towards the naive pluripotent state should be confirmed by a detailed characterization of the cells, as described in this chapter.
2.CREB regulates TNF-α-induced GM-CSF secretion via p38 MAPK in human lung fibroblasts.
Koga Y1, Hisada T2, Ishizuka T3, Utsugi M4, Ono A2, Yatomi M2, Kamide Y5, Aoki-Saito H2, Tsurumaki H2, Dobashi K6, Yamada M2. Allergol Int. 2016 Apr 21. pii: S1323-8930(16)30028-4. doi: 10.1016/j.alit.2016.03.006. [Epub ahead of print]
BACKGROUND: Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a cytokine that mediates eosinophilic differentiation, migration and survival, causing respiratory tract inflammation. GM-CSF is also known to be secreted from respiratory tract structural cells. However, the mechanisms of GM-CSF secretion have not been well established.
3.[Effect of Kanli Granule on Myocardial Mechanics in Pressure Overload Induced Diastolic Heart Failure Rats].
Liu YM, Wu DZ, Xu YY, Teng MZ, Jiang MX. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2016 Feb;36(2):196-202.
OBJECTIVE: To observe the effect of Kanli Granule (KG) on myocardial mechanics in pressure overload induced diastolic heart failure (DHF) rats.
4.The Labdane Ent-3-Acetoxy-Labda-8(17), 13-Dien-15-Oic Decreases Blood Pressure In Hypertensive Rats.
Simplicio JA1, Simão MR2, Ambrosio SR2, Tirapelli CR3. Arq Bras Cardiol. 2016 Apr 19. pii: S0066-782X2016005011102. [Epub ahead of print]
BACKGROUND: Labdane-type diterpenes induce lower blood pressure via relaxation of vascular smooth muscle; however, there are no studies describing the effects of labdanes in hypertensive rats.
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