Fosfadecin
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| Category | Antibiotics |
| Catalog number | BBF-01436 |
| CAS | 120909-50-4 |
| Molecular Weight | 467.27 |
| Molecular Formula | C13H19N5O10P2 |
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Description
Fosfadecin is produced by the strain of Pseudomonas fluorescens PK-5. It has a weak antibacterial activity, the ED50 of Escherichia coli O-111 and Staphylococcus aureus 308A-1 was 800mg/kg and 566mg/kg (mice, oral).
Specification
| Synonyms | Tan 930; 9-[5-O-(Hydroxy{[hydroxy(3-methyloxiran-2-yl)phosphoryl]oxy}phosphoryl)pentofuranosyl]-9H-purin-6-amine |
| IUPAC Name | [[5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-(3-methyloxiran-2-yl)phosphinic acid |
| Canonical SMILES | CC1C(O1)P(=O)(O)OP(=O)(O)OCC2C(C(C(O2)N3C=NC4=C(N=CN=C43)N)O)O |
| InChI | InChI=1S/C13H19N5O10P2/c1-5-13(26-5)29(21,22)28-30(23,24)25-2-6-8(19)9(20)12(27-6)18-4-17-7-10(14)15-3-16-11(7)18/h3-6,8-9,12-13,19-20H,2H2,1H3,(H,21,22)(H,23,24)(H2,14,15,16) |
| InChI Key | XLKKASKVRUMAHE-UHFFFAOYSA-N |
Properties
| Appearance | White Powder |
| Antibiotic Activity Spectrum | fungi |
| Boiling Point | 840.9°C at 760 mmHg |
| Density | 2.34 g/cm3 |
Reference Reading
1. Fosfadecin and fosfocytocin, new nucleotide antibiotics produced by bacteria
N Katayama, S Tsubotani, Y Nozaki, S Harada, H Ono J Antibiot (Tokyo). 1990 Mar;43(3):238-46. doi: 10.7164/antibiotics.43.238.
Two new nucleotide antibiotics, fosfadecin and fosfocytocin, have been isolated from the culture filtrates of Pseudomonas viridiflava PK-5 and Pseudomonas fluorescens PK-52, respectively. These antibiotics were purified by column chromatographies using adsorption, gel filtration and ion exchange resins. On the basis of the spectroscopic and degradation studies, the chemical structures of fosfadecin and fosfocytocin were determined. These antibiotics were either enzymatically or chemically hydrolyzed to generate fosfomycin and a new antibiotic, fosfoxacin, which are also produced in the culture filtrates. They showed antibacterial activity against Gram-positive and Gram-negative bacteria. The antibacterial activity of these nucleotide antibiotics was weaker than that of fosfomycin and fosfoxacin.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
