Fosmidomycin
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
| Category | Antibiotics |
| Catalog number | BBF-03693 |
| CAS | 66508-53-0 |
| Molecular Weight | 183.10 |
| Molecular Formula | C4H10NO5P |
| Purity | 95% |
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Description
Fosmidomycin is produced by the strain of Streptomyces lavendulae 8006. Fosmidomycin has anti-gram-positive and anti-gram-negative activities.
Specification
| Synonyms | Fosmidomycina; 3-(N-hydroxyformamido)propylphosphonic acid; FR-31564 |
| IUPAC Name | 3-[formyl(hydroxy)amino]propylphosphonic acid |
| Canonical SMILES | C(CN(C=O)O)CP(=O)(O)O |
| InChI | InChI=1S/C4H10NO5P/c6-4-5(7)2-1-3-11(8,9)10/h4,7H,1-3H2,(H2,8,9,10) |
| InChI Key | GJXWDTUCERCKIX-UHFFFAOYSA-N |
Properties
| Appearance | White to Beige Powder |
| Antibiotic Activity Spectrum | Gram-positive bacteria; Gram-negative bacteria |
| Boiling Point | 463.7°C at 760 mmHg |
| Density | 1.581 g/cm3 |
Reference Reading
1.Stimulatory effects of centrally injected kainate and N-methyl-D-aspartate on gastric acid secretion in anesthetized rats.
Tsuchiya S1, Horie S, Yano S, Watanabe K. Brain Res. 2001 Sep 28;914(1-2):115-22.
The effects of N-methyl-D-aspartate (NMDA), kainate and (+/-)-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA), ionotropic glutamate agonists, on gastric acid secretion were investigated in the continuously perfused stomach of anesthetized rats. The lateral ventricular (LV) injection of kainate (0.01-1 microg) or NMDA (0.3-3 microg) dose-dependently stimulated gastric acid secretion. AMPA (3-10 microg) also stimulated gastric acid secretion but the effect was very weak. Repeated injections of kainate (0.1 microg) or NMDA (1 microg), at least twice, stimulated gastric acid secretion to a similar degree. The effect of kainate (0.1 microg) was blocked by the kainate receptor antagonists, 6-cyano-7-nitroquinoxaline-2,3-dione disodium (3 microg, LV) and D-gamma-glutamylaminomethanesulfonic acid (30 microg, LV), but not by NMDA receptor antagonists. The effect of NMDA (10 microg) was blocked by (+/-)-3-(2-carboxypiperazin-4-yl)-1-propylphosphonic acid (10 microg, LV), a competitive NMDA receptor antagonist, and (+)-5-methyl-10,11-dihydro-5H-dibenzocyclo-hepten-5,10-imine hydrogen maleate (10 microg, LV), a non-competitive NMDA receptor antagonist, but not by kainate receptor antagonists.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
