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FR-191512

Name: FR-191512
Brand: BOC Sciences
Rating: 5 (1 reviews)

* Please be kindly noted products are not for therapeutic use. We do not sell to patients.

Category	Antibiotics
Catalog number	BBF-03554
CAS
Molecular Weight	750.70
Molecular Formula	C38H38O16

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Capabilities & Facilities

Fermentation Lab

4 R&D and scale-up labs

2 Preparative purification labs

Fermentation Plant

Semi pilot, pilot and industrial plant 4 Manufacturing sites 7 Production lines at pilot scale 100+ Reactors of 30-4000 L; 170+ reactors of 20 KL-30 KL; 24+ reactors of >100 KL 2 Hydrogenation reactors (200 L, 4Mpa and 1000L, 4Mpa)

Product Description

It is a polyphenolic compound with anti-influenza A virus effect.

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Synonyms	FR191512
IUPAC Name	2-[2-[2-[2-[2-[2-(2,4-dihydroxy-6-methylbenzoyl)oxypropyl]-4,6-dihydroxybenzoyl]oxypropyl]-4,6-dihydroxybenzoyl]oxypropyl]-4,6-dihydroxybenzoic acid
Canonical SMILES	CC1=CC(=CC(=C1C(=O)OC(C)CC2=C(C(=CC(=C2)O)O)C(=O)OC(C)CC3=C(C(=CC(=C3)O)O)C(=O)OC(C)CC4=C(C(=CC(=C4)O)O)C(=O)O)O)O
InChI	InChI=1S/C38H38O16/c1-16-5-23(39)12-27(43)31(16)36(49)52-18(3)7-21-10-25(41)14-29(45)33(21)38(51)54-19(4)8-22-11-26(42)15-30(46)34(22)37(50)53-17(2)6-20-9-24(40)13-28(44)32(20)35(47)48/h5,9-15,17-19,39-46H,6-8H2,1-4H3,(H,47,48)
InChI Key	HCXQIVLHUHTXGC-UHFFFAOYSA-N

Appearance	Colorless Powder
Antibiotic Activity Spectrum	viruses
Melting Point	135-138°C

1. FR191512, a novel anti-influenza agent isolated from a fungus strain No.17415. II. Biological properties

Y Nishihara, E Tsujii, Y Yamagishi, T Kino, M Hino, M Yamashita, S Hashimoto J Antibiot (Tokyo). 2000 Dec;53(12):1341-5. doi: 10.7164/antibiotics.53.1341.

FR191512, a novel polyphenolic compound, inhibited the infectivity of influenza A virus in Madin-Darby canine kidney (MDCK) cells in vitro. Furthermore, FR191512 showed good in vivo anti-influenza activity in a mouse model of intranasal infection with influenza A virus. The cytotoxic activity of FR191512 against MDCK cells was very weak.

2. FR191512, a novel anti-influenza agent isolated from a fungus strain No.17415. I. Taxonomy, fermentation, isolation, physico-chemical properties and structure elucidation

Y Nishihara, E Tsujii, S Takase, Y Tsurumi, T Kino, M Hino, M Yamashita, S Hashimoto J Antibiot (Tokyo). 2000 Dec;53(12):1333-40. doi: 10.7164/antibiotics.53.1333.

In the course of our screening for anti-influenza agents of microbial origin, FR191512 was isolated from the cultured broth of fungus strain No. 17415 as colorless powder. The structure of FR191512 was determined by several spectroscopic experiments as a novel polyphenolic compound. This compound showed potent antiviral activity against influenza A virus.

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