FR-191512
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| Category | Antibiotics |
| Catalog number | BBF-03554 |
| CAS | |
| Molecular Weight | 750.70 |
| Molecular Formula | C38H38O16 |
Online Inquiry
Description
It is a polyphenolic compound with anti-influenza A virus effect.
Specification
| Synonyms | FR191512 |
| IUPAC Name | 2-[2-[2-[2-[2-[2-(2,4-dihydroxy-6-methylbenzoyl)oxypropyl]-4,6-dihydroxybenzoyl]oxypropyl]-4,6-dihydroxybenzoyl]oxypropyl]-4,6-dihydroxybenzoic acid |
| Canonical SMILES | CC1=CC(=CC(=C1C(=O)OC(C)CC2=C(C(=CC(=C2)O)O)C(=O)OC(C)CC3=C(C(=CC(=C3)O)O)C(=O)OC(C)CC4=C(C(=CC(=C4)O)O)C(=O)O)O)O |
| InChI | InChI=1S/C38H38O16/c1-16-5-23(39)12-27(43)31(16)36(49)52-18(3)7-21-10-25(41)14-29(45)33(21)38(51)54-19(4)8-22-11-26(42)15-30(46)34(22)37(50)53-17(2)6-20-9-24(40)13-28(44)32(20)35(47)48/h5,9-15,17-19,39-46H,6-8H2,1-4H3,(H,47,48) |
| InChI Key | HCXQIVLHUHTXGC-UHFFFAOYSA-N |
Properties
| Appearance | Colorless Powder |
| Antibiotic Activity Spectrum | viruses |
| Melting Point | 135-138°C |
Reference Reading
1. FR191512, a novel anti-influenza agent isolated from a fungus strain No.17415. II. Biological properties
Y Nishihara, E Tsujii, Y Yamagishi, T Kino, M Hino, M Yamashita, S Hashimoto J Antibiot (Tokyo). 2000 Dec;53(12):1341-5. doi: 10.7164/antibiotics.53.1341.
FR191512, a novel polyphenolic compound, inhibited the infectivity of influenza A virus in Madin-Darby canine kidney (MDCK) cells in vitro. Furthermore, FR191512 showed good in vivo anti-influenza activity in a mouse model of intranasal infection with influenza A virus. The cytotoxic activity of FR191512 against MDCK cells was very weak.
2. FR191512, a novel anti-influenza agent isolated from a fungus strain No.17415. I. Taxonomy, fermentation, isolation, physico-chemical properties and structure elucidation
Y Nishihara, E Tsujii, S Takase, Y Tsurumi, T Kino, M Hino, M Yamashita, S Hashimoto J Antibiot (Tokyo). 2000 Dec;53(12):1333-40. doi: 10.7164/antibiotics.53.1333.
In the course of our screening for anti-influenza agents of microbial origin, FR191512 was isolated from the cultured broth of fungus strain No. 17415 as colorless powder. The structure of FR191512 was determined by several spectroscopic experiments as a novel polyphenolic compound. This compound showed potent antiviral activity against influenza A virus.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
