FR-198248
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| Category | Antibiotics |
| Catalog number | BBF-03694 |
| CAS | 197316-54-4 |
| Molecular Weight | 198.17 |
| Molecular Formula | C9H10O5 |
| Purity | >98% |
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Description
FR-198248, a new type of hydroxyl benzaldehyde compound, was isolated from the cultured broth of a fungal strain identified as Aspergillus terreus from morphological characteristics. FR-198248 exhibited anti-influenza virus activity in Madin-Darby canine kidney (MDCK) cells in vitro.
Specification
| Synonyms | fr198248; 1,3-Dihydro-4-methyl-1,5,6,7-isobenzofurantetraol |
| IUPAC Name | 4-methyl-1,3-dihydro-2-benzofuran-1,5,6,7-tetrol |
| Canonical SMILES | CC1=C2COC(C2=C(C(=C1O)O)O)O |
| InChI | InChI=1S/C9H10O5/c1-3-4-2-14-9(13)5(4)7(11)8(12)6(3)10/h9-13H,2H2,1H3 |
| InChI Key | GSKYCPXSDLXGEW-UHFFFAOYSA-N |
Properties
| Appearance | White Powder |
| Antibiotic Activity Spectrum | viruses |
| Boiling Point | 419.6±40.0°C at 760 mmHg |
| Density | 1.6±0.1 g/cm3 |
Reference Reading
1. New anti-influenza agents, FR198248 and its derivatives. II. Characterization of FR198248, its related compounds and some derivatives
S Hashimoto, Y Nishihara, S Takase, E Tsujii, H Hatanaka J Antibiot (Tokyo) . 2001 Mar;54(3):297-303. doi: 10.7164/antibiotics.54.297.
We isolated FR198248 from the cultured broth of Aspergillus terreus No. 13830 as a new anti-influenza agents. The structure of FR198248 was elucidated by several spectroscopic experiments as a novel tetrahydroxybenzaldehyde compound. Furthermore, we described the characteristics of FR198248, its related compounds and some derivatives.
2. Isolation and identification of FR198248, a hydroxylated 1,3-dihydroisobenzofuran, from Aspergillus flavipes as an inhibitor of peptide deformylase
Won-Gon Kim, Yun-Ju Kwon, Chang-Ji Zheng Biosci Biotechnol Biochem . 2010;74(2):390-3. doi: 10.1271/bbb.90565.
Two highly hydroxylated 1,3-dihydroisobenzofurans, FR198248 (1) and FR202306 (2), were isolated as peptide deformylase (PDF) inhibitors from Aspergillus flavipes. Compounds 1 and 2 inhibited Staphylococus aureus PDF with IC(50) values of 3.6 and 2.5 microM, respectively, and also showed antibacterial activity with an MIC value of 25 microg/ml. In contrast, 6-O-methyl derivative 3 of compound 2 was inactive against both PDF and S. aureus.
3. FR198248, a new anti-influenza agent isolated from Apsergillus terreus No 13830. I. Taxomony, fermentation, isolation, physico-chemical properties and biological activities
T Kino, M Hino, S Hashimoto, Y Nishihara, R Ohtsu, S Furukawa, Y Tsurumi, K Sakamoto, E Tsujii, Y Yamagishi, M Yamashita J Antibiot (Tokyo) . 2001 Feb;54(2):136-43. doi: 10.7164/antibiotics.54.136.
A novel anti-influenza agent, FR198248, was isolated from the cultured broth of a fungal strain No.13830. The strain was identified as Aspergillus terreus from morphological characteristics. FR198248, a new type of hydroxyl benzaldehyde compound, showed antiinfluenza virus activity in Madin-Darby canine kidney (MDCK) cells in vitro. The mode of action of FR198248 against influenza virus A could be ascribed to an inhibitory effect on the stage of virus adsorption. Furthermore, FR198248 possessed potent in vivo anti-influenza activity in a murine model of respiratory tract infection.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
