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FR 900130

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FR 900130
Category Antibiotics
Catalog number BBF-03560
CAS 73537-09-4
Molecular Weight 99.09
Molecular Formula C4H5NO2
Purity >95%

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Capabilities & Facilities

Fermentation Lab

4 R&D and scale-up labs

2 Preparative purification labs

Fermentation Plant

Semi pilot, pilot and industrial plant 4 Manufacturing sites 7 Production lines at pilot scale 100+ Reactors of 30-4000 L; 170+ reactors of 20 KL-30 KL; 24+ reactors of >100 KL 2 Hydrogenation reactors (200 L, 4Mpa and 1000L, 4Mpa)

Product Description

FR 900130, isolated from Streptomyces catenulae, is an antibiotic easily to decompose. It has anti-gram-positive and anti-gram-negative activities, and has a synergistic effect with D-cycloserine.

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Synonyms L-2-amino-3-butynoic acid; Antibiotic FR 900130; (S)-2-Amino-3-butynoic acid
IUPAC Name (2S)-2-aminobut-3-ynoic acid
Canonical SMILES C#CC(C(=O)O)N
InChI InChI=1S/C4H5NO2/c1-2-3(5)4(6)7/h1,3H,5H2,(H,6,7)/t3-/m0/s1
InChI Key DSUAJFIEKRKPEE-VKHMYHEASA-N
Antibiotic Activity Spectrum Gram-positive bacteria; Gram-negative bacteria
Boiling Point 275°C at 760 mmHg
Density 1.286 g/cm3
Solubility Soluble in Water
1. FR-900130, a novel amino acid antibiotic. II. Isolation and structure elucidation of the acetyl derivative of FR-900130
Y Kuroda, M Okuhara, T Goto, M Kohsaka, H Aoki, H Imanaka J Antibiot (Tokyo). 1980 Feb;33(2):132-6. doi: 10.7164/antibiotics.33.132.
FR-900130 is a new antibiotic having an acetylene moiety and is very unstable in aqueous solution. The antibiotic was isolated as the acetyl derivative by ion-exchange resin and adsorption chromatography. The structure has been determined to be L-2-amino-3-butynoic acid by spectral data of its derivatives.
2. FR-900130, a novel amino acid antibiotic. I. Discovery, taxonomy, isolation, and properties
Y Kuroda, M Okuhara, T Goto, E Iguchi, M Kohsaka, H Aoki, H Imanaka J Antibiot (Tokyo). 1980 Feb;33(2):125-31. doi: 10.7164/antibiotics.33.125.
A new antibiotic, designated FR-900130, has been discovered in the culture filtrate of Streptomyces. The producing organism has been identified as Streptomyces catenulae. The antibiotic was purified by adsorption onto Duolite C-20, passage through Amberlite IRC-50, final purification and desalting on Sephadex G-25. It shows antimicrobial activity against Gram-positive bacteria and synergy with D-cycloserine. The antibiotic is very labile in alkaline solution above pH 8.0 and decomposed during lyophilization or solvent precipitation. It was converted to an acetyl derivative and the biological properties of the derivative were examined.

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