FR 900130
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| Category | Antibiotics |
| Catalog number | BBF-03560 |
| CAS | 73537-09-4 |
| Molecular Weight | 99.09 |
| Molecular Formula | C4H5NO2 |
| Purity | >95% |
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Description
FR 900130, isolated from Streptomyces catenulae, is an antibiotic easily to decompose. It has anti-gram-positive and anti-gram-negative activities, and has a synergistic effect with D-cycloserine.
Specification
| Synonyms | L-2-amino-3-butynoic acid; Antibiotic FR 900130; (S)-2-Amino-3-butynoic acid |
| IUPAC Name | (2S)-2-aminobut-3-ynoic acid |
| Canonical SMILES | C#CC(C(=O)O)N |
| InChI | InChI=1S/C4H5NO2/c1-2-3(5)4(6)7/h1,3H,5H2,(H,6,7)/t3-/m0/s1 |
| InChI Key | DSUAJFIEKRKPEE-VKHMYHEASA-N |
Properties
| Antibiotic Activity Spectrum | Gram-positive bacteria; Gram-negative bacteria |
| Boiling Point | 275°C at 760 mmHg |
| Density | 1.286 g/cm3 |
| Solubility | Soluble in Water |
Reference Reading
1. FR-900130, a novel amino acid antibiotic. II. Isolation and structure elucidation of the acetyl derivative of FR-900130
Y Kuroda, M Okuhara, T Goto, M Kohsaka, H Aoki, H Imanaka J Antibiot (Tokyo). 1980 Feb;33(2):132-6. doi: 10.7164/antibiotics.33.132.
FR-900130 is a new antibiotic having an acetylene moiety and is very unstable in aqueous solution. The antibiotic was isolated as the acetyl derivative by ion-exchange resin and adsorption chromatography. The structure has been determined to be L-2-amino-3-butynoic acid by spectral data of its derivatives.
2. FR-900130, a novel amino acid antibiotic. I. Discovery, taxonomy, isolation, and properties
Y Kuroda, M Okuhara, T Goto, E Iguchi, M Kohsaka, H Aoki, H Imanaka J Antibiot (Tokyo). 1980 Feb;33(2):125-31. doi: 10.7164/antibiotics.33.125.
A new antibiotic, designated FR-900130, has been discovered in the culture filtrate of Streptomyces. The producing organism has been identified as Streptomyces catenulae. The antibiotic was purified by adsorption onto Duolite C-20, passage through Amberlite IRC-50, final purification and desalting on Sephadex G-25. It shows antimicrobial activity against Gram-positive bacteria and synergy with D-cycloserine. The antibiotic is very labile in alkaline solution above pH 8.0 and decomposed during lyophilization or solvent precipitation. It was converted to an acetyl derivative and the biological properties of the derivative were examined.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
