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FR 900137

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Category Antibiotics
Catalog number BBF-03561
CAS 73706-58-8
Molecular Weight 253.24
Molecular Formula C8H20N3O4P

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Capabilities & Facilities

Fermentation Lab

4 R&D and scale-up labs

2 Preparative purification labs

Fermentation Plant

Semi pilot, pilot and industrial plant 4 Manufacturing sites 7 Production lines at pilot scale 100+ Reactors of 30-4000 L; 170+ reactors of 20 KL-30 KL; 24+ reactors of >100 KL 2 Hydrogenation reactors (200 L, 4Mpa and 1000L, 4Mpa)

Product Description

FR 900137 is produced by the strain of Streptomyces unzenensis 2050. It has a broad spectrum of antibacterial activity and has a strong effect on Pseudomonas aeruginosa Ⅳ.

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Synonyms Antibiotic FR 900137; L-Leucine, 2-(hydroxymethoxyphosphinyl)-2-methylhydrazide; 2-Amino-N-[hydroxy(methoxy)phosphoryl]-N,4-dimethylpentanehydrazonic acid
IUPAC Name N-[[(2S)-2-amino-4-methylpentanoyl]amino]-methoxy-N-methylphosphonamidic acid
Canonical SMILES CC(C)CC(C(=O)NN(C)P(=O)(O)OC)N
InChI InChI=1S/C8H20N3O4P/c1-6(2)5-7(9)8(12)10-11(3)16(13,14)15-4/h6-7H,5,9H2,1-4H3,(H,10,12)(H,13,14)/t7-/m0/s1
InChI Key JGZNDHCOJBAROW-ZETCQYMHSA-N
Appearance White Powder
Antibiotic Activity Spectrum Gram-negative bacteria
Melting Point 134°C
Density 1.2±0.1 g/cm3
Solubility Soluble in Water, Methanol
1. FR-900137, a new antibiotic. II. Structure determination of FR-900137
Y Kuroda, H Tanaka, M Okamoto, T Goto, M Kohsaka, H Aoki, H Imanaka J Antibiot (Tokyo). 1980 Mar;33(3):280-3. doi: 10.7164/antibiotics.33.280.
The structure of FR-900137, a new antibiotic produced by a new strain of Streptomyces has been established as methyl hydrogen N1-methyl N2-(L)-leucyl phosphorohydrazidate on the basis of spectroscopic and chemical evidence.
2. FR-900137, a new antibiotic. I. Taxonomy and fermentation of the organism, and isolation and characterization of the antibiotic
Y Kuroda, T Goto, M Okamoto, M Yamashita, E Iguchi, M Kohsaka, H Aoki, H Imanaka J Antibiot (Tokyo). 1980 Mar;33(3):272-9. doi: 10.7164/antibiotics.33.272.
A strain of Streptomyces, isolated from a soild sample and identified as Streptomyces unzenensis sp. nov. has been found to produce FR-900137, an interesting new antibiotic, containing phosphorus in its molecule. The antibiotic, obtained as white powder, was shown to inhibit a wide variety of Gram-positive and Gram-negative bacteria except Pseudomonas aeruginosa.

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