FR 900137
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| Category | Antibiotics |
| Catalog number | BBF-03561 |
| CAS | 73706-58-8 |
| Molecular Weight | 253.24 |
| Molecular Formula | C8H20N3O4P |
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Description
FR 900137 is produced by the strain of Streptomyces unzenensis 2050. It has a broad spectrum of antibacterial activity and has a strong effect on Pseudomonas aeruginosa Ⅳ.
Specification
| Synonyms | Antibiotic FR 900137; L-Leucine, 2-(hydroxymethoxyphosphinyl)-2-methylhydrazide; 2-Amino-N-[hydroxy(methoxy)phosphoryl]-N,4-dimethylpentanehydrazonic acid |
| IUPAC Name | N-[[(2S)-2-amino-4-methylpentanoyl]amino]-methoxy-N-methylphosphonamidic acid |
| Canonical SMILES | CC(C)CC(C(=O)NN(C)P(=O)(O)OC)N |
| InChI | InChI=1S/C8H20N3O4P/c1-6(2)5-7(9)8(12)10-11(3)16(13,14)15-4/h6-7H,5,9H2,1-4H3,(H,10,12)(H,13,14)/t7-/m0/s1 |
| InChI Key | JGZNDHCOJBAROW-ZETCQYMHSA-N |
Properties
| Appearance | White Powder |
| Antibiotic Activity Spectrum | Gram-negative bacteria |
| Melting Point | 134°C |
| Density | 1.2±0.1 g/cm3 |
| Solubility | Soluble in Water, Methanol |
Reference Reading
1. FR-900137, a new antibiotic. II. Structure determination of FR-900137
Y Kuroda, H Tanaka, M Okamoto, T Goto, M Kohsaka, H Aoki, H Imanaka J Antibiot (Tokyo). 1980 Mar;33(3):280-3. doi: 10.7164/antibiotics.33.280.
The structure of FR-900137, a new antibiotic produced by a new strain of Streptomyces has been established as methyl hydrogen N1-methyl N2-(L)-leucyl phosphorohydrazidate on the basis of spectroscopic and chemical evidence.
2. FR-900137, a new antibiotic. I. Taxonomy and fermentation of the organism, and isolation and characterization of the antibiotic
Y Kuroda, T Goto, M Okamoto, M Yamashita, E Iguchi, M Kohsaka, H Aoki, H Imanaka J Antibiot (Tokyo). 1980 Mar;33(3):272-9. doi: 10.7164/antibiotics.33.272.
A strain of Streptomyces, isolated from a soild sample and identified as Streptomyces unzenensis sp. nov. has been found to produce FR-900137, an interesting new antibiotic, containing phosphorus in its molecule. The antibiotic, obtained as white powder, was shown to inhibit a wide variety of Gram-positive and Gram-negative bacteria except Pseudomonas aeruginosa.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
