FR-900490
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| Category | Antibiotics |
| Catalog number | BBF-03696 |
| CAS | 105424-59-7 |
| Molecular Weight | 370.36 |
| Molecular Formula | C14H22N6O6 |
| Purity | >98% |
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Description
FR-900490 is a new type of immunoactive substance isolated from Disocia sp. F-11809. It is effective in reversing the damage to bone marrow caused by mitomycin C.
Specification
| Synonyms | FR 900490; FR900490; BMY 28700; BMY28700; BMY-28700; (2S,3R)-2-[(L-Asparaginyl)amino]-3-[[(S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino]butanoic acid |
| Shelf Life | 2 month in rt, long time |
| Storage | Store at -20°C |
| IUPAC Name | (2S,3R)-3-[[(1S)-1-carboxy-2-(1H-imidazol-5-yl)ethyl]amino]-2-[[(2S)-2,4-diamino-4-oxobutanoyl]amino]butanoic acid |
| Canonical SMILES | CC(C(C(=O)O)NC(=O)C(CC(=O)N)N)NC(CC1=CN=CN1)C(=O)O |
| InChI | InChI=1S/C14H22N6O6/c1-6(19-9(13(23)24)2-7-4-17-5-18-7)11(14(25)26)20-12(22)8(15)3-10(16)21/h4-6,8-9,11,19H,2-3,15H2,1H3,(H2,16,21)(H,17,18)(H,20,22)(H,23,24)(H,25,26)/t6-,8+,9+,11+/m1/s1 |
| InChI Key | SJMNSEOOTVHHOW-PBCZWWQYSA-N |
Properties
| Appearance | Colorless Powder |
| Application | FR-900490 is effective in reversing the damage to bone marrow caused by mitomycin C. |
| Boiling Point | 890.0±65.0°C at 760 mmHg |
| Melting Point | 174°C |
| Density | 1.5±0.1 g/cm3 |
| Solubility | 10 mM in DMSO |
Reference Reading
1. A new immunomodulator, FR-900490
M Okuhara,T Shibata,O Nakayama,M Kohsaka,H Terano,Y Tsurumi J Antibiot (Tokyo) . 1988 Sep;41(9):1163-9. doi: 10.7164/antibiotics.41.1163.
FR-900490 is a new type of immunoactive substance produced by a fungus Discosia sp. F-11809. The colony forming units in culture (cfu-c) in bone marrow cells, which were suppressed by immunosuppressive factor obtained from the serum of sarcoma 180 tumor bearing mouse, was restored to normal level by the addition of FR-900490 in vitro. Furthermore, in mitomycin C (MMC)-treated mice the subsequent administration of FR-900490 caused a significant increase of cfu-c in bone marrow cells depressed by MMC.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
