Fujianmycin A
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
| Category | Antibiotics |
| Catalog number | BBF-01448 |
| CAS | 96695-57-7 |
| Molecular Weight | 322.31 |
| Molecular Formula | C19H14O5 |
Online Inquiry
Description
It is produced by the strain of Streptomyces sp. Fujianmycin A has anti-subtilis activity.
Specification
| Synonyms | (3s,4r)-4,8-dihydroxy-3-methyl-3,4-dihydrotetraphene-1,7,12(2h)-trione; O-Demethylrubiginone A2; 4,8-Dihydroxy-3-methyl-3,4-dihydrotetraphene-1,7,12(2H)-trione |
| IUPAC Name | (3S,4R)-4,8-dihydroxy-3-methyl-3,4-dihydro-2H-benzo[a]anthracene-1,7,12-trione |
| Canonical SMILES | CC1CC(=O)C2=C(C1O)C=CC3=C2C(=O)C4=C(C3=O)C(=CC=C4)O |
| InChI | InChI=1S/C19H14O5/c1-8-7-13(21)14-10(17(8)22)5-6-11-16(14)19(24)9-3-2-4-12(20)15(9)18(11)23/h2-6,8,17,20,22H,7H2,1H3/t8-,17+/m0/s1 |
| InChI Key | WWVNIBVFNYKUQY-WNWIJWBNSA-N |
Properties
| Appearance | Yellow Acicular Crystalline |
| Antibiotic Activity Spectrum | fungi |
| Melting Point | 182-185°C |
Reference Reading
1. Saccharosporones A, B and C, cytotoxic antimalarial angucyclinones from Saccharopolyspora sp. BCC 21906
Chollaratt Boonlarppradab, Chanwit Suriyachadkun, Pranee Rachtawee, Wilunda Choowong J Antibiot (Tokyo). 2013 Jun;66(6):305-9. doi: 10.1038/ja.2013.16. Epub 2013 Apr 3.
Three new angucyclinones, saccharosporones A, B and C, together with (+)-ochromycinone, (+)-rubiginone B2, tetrangulol methyl ether and fujianmycin A, were obtained from fermentation of the terrestrial actinomycete of the genus Saccharopolyspora BCC 21906 isolated from a soil collected in Chanthaburi Province, Thailand. Structures of the new compounds and their relative configurations were assigned by NMR spectral data interpretation. Saccharosporones A and B exhibited antimalarial activity against Plasmodium falciparum K1 with IC50 values of 4.1 and 3.9 μM. Both metabolites also possessed cytotoxic activities against cancer cell lines (KB, MCF-7 and NCI-H187) and nonmalignant Vero cell, while saccharosporone C only showed cytotoxic activity against NCI-H187.
2. Angucyclinones from an Indonesian Streptomyces sp
Serge Fotso, Taifo Mahmud, T Mark Zabriskie, Dwi Andreas Santosa, Sulastri, Philip J Proteau J Nat Prod. 2008 Jan;71(1):61-5. doi: 10.1021/np0704102. Epub 2007 Dec 15.
Six new angucyclinone polyketides named panglimycins A-F were isolated together with the three known metabolites (+)-fujianmycin A, (+)-ochromycinone, and emycin C from the bioassay-guided fractionation of the extract of the Indonesian Streptomyces strain ICBB8230. The new compounds are highly oxygenated angucyclinones that appear to be biosynthetically derived from ochromycinone or fujianmycin. Their structures were determined by X-ray crystal analysis, interpretation of 1D- and 2D-NMR spectra, and comparison of the data with those of structurally related known natural products. Despite structural similarities to angucyclinones with antibiotic activities, the panglimycins did not exhibit any growth inhibition when tested against several bacteria and fungi.
Recommended Products
| BBF-00677 | 3-Amino-3-deoxy-D-glucose | Inquiry |
| BBF-02642 | Lactonamycin | Inquiry |
| BBF-01825 | Loganin | Inquiry |
| BBF-01829 | Deoxynojirimycin | Inquiry |
| BBF-03753 | Baicalin | Inquiry |
| BBF-05862 | Epirubicin | Inquiry |
Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
