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Fumaramidmycin

Name: Fumaramidmycin
Brand: BOC Sciences
Rating: 5 (1 reviews)

* Please be kindly noted products are not for therapeutic use. We do not sell to patients.

Category	Antibiotics
Catalog number	BBF-01852
CAS	57687-92-0
Molecular Weight	232.23
Molecular Formula	C12H12N2O3
Purity	≥98%

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Semi pilot, pilot and industrial plant 4 Manufacturing sites 7 Production lines at pilot scale 100+ Reactors of 30-4000 L; 170+ reactors of 20 KL-30 KL; 24+ reactors of >100 KL 2 Hydrogenation reactors (200 L, 4Mpa and 1000L, 4Mpa)

Product Description

An antibiotic originally isolated from Streptomyces kurssanovii NR-7GG1. It has the activity against gram-positive bacteria and negative bacteria (individual).

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Synonyms	Antibiotic C 9154; trans-N-(Phenylacetyl)-2-butenediamide; Ro 09-0049; N1-(2-phenylacetyl)fumaramide
IUPAC Name	(E)-N'-(2-phenylacetyl)but-2-enediamide
Canonical SMILES	C1=CC=C(C=C1)CC(=O)NC(=O)C=CC(=O)N
InChI	InChI=1S/C12H12N2O3/c13-10(15)6-7-11(16)14-12(17)8-9-4-2-1-3-5-9/h1-7H,8H2,(H2,13,15)(H,14,16,17)/b7-6+
InChI Key	RPPKWABVORYKHA-VOTSOKGWSA-N

Appearance	Colorless Crystalline
Antibiotic Activity Spectrum	Gram-positive bacteria; Gram-negative bacteria
Boiling Point	510.8°C at 760 mmHg
Melting Point	202-203°C
Density	1.25 g/cm3
Solubility	Soluble in DMF, DMSO

1. A new antibiotic, fumaramidmycin. II. Isolation, structure and syntheses

Y Suhara, H B Maruyama, Y Koto, Y Miyasaka, K Yokose J Antibiot (Tokyo). 1975 Sep;28(9):648-55. doi: 10.7164/antibiotics.28.648.

A new antibiotic fumaramidmycin produced by Streptomyces kurssanovii NR-7GG1 was isolated as colorless crystals. The structure was shown to be N-(phenylacetyl) fumaramide. Starting from fumaramic acid, fumaramidmycin has been synthesized in good yield, in which the key stage involves N-acylated imino ether formation followed by mild acid hydrolysis. Five analogues of fumaramidmycin have also been prepared.

2. A new antibiotic, fumaramidmycin I. Production, biological properties and characterization of producer strain

H B Maruyama, Y Suhara, J Suzuki-Watanabe, Y Maeshima, N Shimizu J Antibiot (Tokyo). 1975 Sep;28(9):636-47. doi: 10.7164/antibiotics.28.636.

A new antibiotic, fumaramidmycin, has been isolated from a streptomycete NR-7GG1 which was characterized and named Streptomyces kurssanovii. The strain produced the antibiotic only when grown on agar plates but not in the submerged culture broth, where the contact with the vegetative mycelia appears to cause the inactivation of the antibiotic. The antibiotic shows an antimicrobial activity against both Gram-positive and Gram-negative bacteria.

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