G 367 S1

G 367 S1

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Category Antibiotics
Catalog number BBF-03574
CAS 76647-54-6
Molecular Weight 475.54
Molecular Formula C20H37N5O8

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Description

It is an aminoglycoside antibiotic which has anti-gram-positive and anti-gram-negative activities.

Specification

Synonyms 2'-N-Formylsisomycin; G-367 S(1); D-Streptamine, O-6-amino-2,3,4,6-tetradeoxy-2-(formylamino)-alpha-D-glycero-hex-4-enopyranosyl-(1-4)-O-(3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl-(1-6))-2-deoxy-, (SP-4-2)-
IUPAC Name N-[(2S,3R)-6-(aminomethyl)-2-[(1R,2S,3S,4R,6S)-4,6-diamino-3-[(2R,3R,4R,5R)-3,5-dihydroxy-5-methyl-4-(methylamino)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-3,4-dihydro-2H-pyran-3-yl]formamide
Canonical SMILES CC1(COC(C(C1NC)O)OC2C(CC(C(C2O)OC3C(CC=C(O3)CN)NC=O)N)N)O
InChI InChI=1S/C20H37N5O8/c1-20(29)7-30-19(14(28)17(20)24-2)33-16-11(23)5-10(22)15(13(16)27)32-18-12(25-8-26)4-3-9(6-21)31-18/h3,8,10-19,24,27-29H,4-7,21-23H2,1-2H3,(H,25,26)/t10-,11+,12+,13-,14+,15+,16-,17+,18+,19+,20-/m0/s1
InChI Key CEKWVQNWPXXMIU-QFPUGEGSSA-N

Properties

Appearance White Powder
Antibiotic Activity Spectrum Gram-positive bacteria; Gram-negative bacteria
Boiling Point 756.2±60.0°C at 760 mmHg
Melting Point 130-133°C
Density 1.4±0.1 g/cm3
Solubility Soluble in Water

Reference Reading

1. A new aminoglycoside antibiotic G-367 S1, 2'-N-formylsisomicin fermentation, isolation and characterization
S Satoi, M Awata, N Muto, M Hayashi, H Sagai, M Otani J Antibiot (Tokyo). 1983 Jan;36(1):1-5. doi: 10.7164/antibiotics.36.1.
A new aminoglycoside antibiotic, G-367 S1 (2'-N-formylsisomicin, C20H37N5O8) produced by a rare actinomycetes, Dactylosporangium thailandense G-367 (FERM-P 4840) has been isolated by column chromatography on a cation-exchange resin. G-367 S1 is active against Gram-positive and Gram-negative bacteria.

Bio Calculators

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L

* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2

* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O c22h30n40
g/mol
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