Gentisyl alcohol
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
| Category | Antibiotics |
| Catalog number | BBF-01869 |
| CAS | 495-08-9 |
| Molecular Weight | 140.14 |
| Molecular Formula | C7H8O3 |
| Purity | 95% |
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Description
Gentisyl alcohol is produced by the strain of Penicillium patulum and Pen. divergens. It has anti-staphylococcus aureus activity.
Specification
| Synonyms | 2,5-Dihydroxybenzyl alcohol; 3,6-Dihydroxybenzyl alcohol; Salirepol; gentisin alcohol |
| IUPAC Name | 2-(hydroxymethyl)benzene-1,4-diol |
| Canonical SMILES | C1=CC(=C(C=C1O)CO)O |
| InChI | InChI=1S/C7H8O3/c8-4-5-3-6(9)1-2-7(5)10/h1-3,8-10H,4H2 |
| InChI Key | PUZSUVGRVHEUQO-UHFFFAOYSA-N |
Properties
| Appearance | Colorless Acicular Crystalline |
| Antibiotic Activity Spectrum | fungi |
| Boiling Point | 299.9°C at 760 mmHg |
| Melting Point | 100-101°C |
| Density | 1.399 g/cm3 |
| Solubility | Soluble in Ethanol, Diethyl ether, Water |
Reference Reading
1.3-Chloro-2,5-dihydroxybenzyl alcohol activates human cervical carcinoma HeLa cell apoptosis by inducing DNA damage.
Zhang Y1, Ahn EY, Jiang Y, Kim DK, Kang SG, Wu C, Kang SW, Park JS, Son BW, Jung JH. Int J Oncol. 2007 Dec;31(6):1317-23.
We have isolated 3-chloro-2,5-dihydroxybenzyl alcohol (CHBA) from marine-derived fungus Aspergillus sp. and characterized its apoptosis-inducing properties against human cervical carcinoma (HeLa) cells. Significantly decreased rates of proliferation and viability (IC50 approximately 35 microM) as well as evidence of apoptosis were observed with CHBA. Nuclear changes observed under fluorescence microscopy confirmed apoptosis occurrence and showed a typical pattern of chromatin condensation. Furthermore, results from Annexin V-FITC/PI dual staining indicated that CHBA induced earlier apoptosis of HeLa cells in a concentration- and time-dependent manner. CHBA also induced cytochrome c release from mitochondria into the cytosol and subsequent caspase activation involving caspase-9 and -3 by Western blotting assay was observed. We also found that CHBA was able to induce DNA damage and inhibit DNA replication followed by S phase arrest. The very sensitive alkaline microgel electrophoresis technique (comet assay) was used for estimation of the CHBA-induced DNA single strand breaks.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
