GERI-BP001 A
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| Category | Enzyme inhibitors |
| Catalog number | BBF-03582 |
| CAS | |
| Molecular Weight | 467.55 |
| Molecular Formula | C27H33NO6 |
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Description
GERI-BP001 A is produced by the strain of Aspergillus fumigatus F37 with inhibitory activity against ACAT.
Specification
| Synonyms | GERI-BP-001A |
| IUPAC Name | [(1S,2S,5S,7R,10R,18S)-18-hydroxy-2,6,6,10-tetramethyl-16-oxo-14-pyridin-3-yl-11,15-dioxatetracyclo[8.8.0.02,7.012,17]octadeca-12(17),13-dien-5-yl] acetate |
| Canonical SMILES | CC(=O)OC1CCC2(C(C1(C)C)CCC3(C2C(C4=C(O3)C=C(OC4=O)C5=CN=CC=C5)O)C)C |
| InChI | InChI=1S/C27H33NO6/c1-15(29)32-20-9-10-26(4)19(25(20,2)3)8-11-27(5)23(26)22(30)21-18(34-27)13-17(33-24(21)31)16-7-6-12-28-14-16/h6-7,12-14,19-20,22-23,30H,8-11H2,1-5H3/t19-,20-,22+,23+,26-,27+/m0/s1 |
| InChI Key | CRIDZJKECHTODK-HJAVCOCOSA-N |
Properties
| Appearance | White Powder |
| Boiling Point | 611.8±55.0°C at 760 mmHg |
| Density | 1.3±0.1 g/cm3 |
Reference Reading
1. GERI-BP001 compounds, new inhibitors of acyl-CoA: cholesterol acyltransferase from Aspergillus fumigatus F37. I. Production, isolation, and physico-chemical and biological properties
T S Jeong, S U Kim, K H Son, B M Kwon, Y K Kim, M U Choi, S H Bok J Antibiot (Tokyo). 1995 Aug;48(8):751-6. doi: 10.7164/antibiotics.48.751.
GERI-BP001 compounds, new inhibitors of acyl-CoA:cholesterol acyltransferase (ACAT), were isolated from a culture broth of Aspergillus fumigatus F37 by acetone extraction, EtOAc extraction, SiO2 column chromatography, and reverse phase HPLC. GERI-BP001 M, A, and B inhibit ACAT activity in an enzyme assay system using rat liver microsomes by 50% at concentrations of 42, 94, and 40 microM, respectively.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
