Gilvusmycin
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| Category | Antibiotics |
| Catalog number | BBF-01247 |
| CAS | 195052-09-6 |
| Molecular Weight | 702.71 |
| Molecular Formula | C38H34N6O8 |
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Description
It is produced by the strain of Streptomyces sp. It is an antibiotic with strong anti-tumor activity. It can inhibit P388, K562, A431 and MKN28 cells with IC50 (ng/mL) of 0.08, 0.86, 0.72 and 0.75, respectively.
Specification
| Synonyms | 6-({6-[(6-acetyl-5-hydroxy-4-methoxy-3,6,7,8-tetrahydropyrrolo[3,2-e]indol-2-yl)carbonyl]-5-hydroxy-4-methoxy-3,6,7,8-tetrahydropyrrolo[3,2-e]indol-2-yl}carbonyl)-3-methyl-4,4a,5,6-tetrahydrocyclopropa[c]pyrrolo[3,2-e]indol-8(1H)-one |
| IUPAC Name | 10-[6-(6-acetyl-5-hydroxy-4-methoxy-7,8-dihydro-3H-pyrrolo[3,2-e]indole-2-carbonyl)-5-hydroxy-4-methoxy-7,8-dihydro-3H-pyrrolo[3,2-e]indole-2-carbonyl]-3-methyl-5,10-diazatetracyclo[7.4.0.01,12.02,6]trideca-2(6),3,8-trien-7-one |
| Canonical SMILES | CC1=CNC2=C1C34CC3CN(C4=CC2=O)C(=O)C5=CC6=C7CCN(C7=C(C(=C6N5)OC)O)C(=O)C8=CC9=C1CCN(C1=C(C(=C9N8)OC)O)C(=O)C |
| InChI | InChI=1S/C38H34N6O8/c1-15-13-39-29-24(46)11-25-38(26(15)29)12-17(38)14-44(25)37(50)23-10-21-19-6-8-43(31(19)33(48)35(52-4)28(21)41-23)36(49)22-9-20-18-5-7-42(16(2)45)30(18)32(47)34(51-3)27(20)40-22/h9-11,13,17,39-41,47-48H,5-8,12,14H2,1-4H3 |
| InChI Key | XUBJLJZOSKJNMY-UHFFFAOYSA-N |
Properties
| Appearance | Yellow Powder |
| Antibiotic Activity Spectrum | Neoplastics (Tumor) |
| Melting Point | 160-162 °C (dec.) |
| Solubility | Soluble in Methanol, DMF |
Reference Reading
1. Structural evolution of a DNA repair self-resistance mechanism targeting genotoxic secondary metabolites
Elwood A Mullins, Jonathan Dorival, Gong-Li Tang, Dale L Boger, Brandt F Eichman Nat Commun. 2021 Nov 26;12(1):6942. doi: 10.1038/s41467-021-27284-7.
Microbes produce a broad spectrum of antibiotic natural products, including many DNA-damaging genotoxins. Among the most potent of these are DNA alkylating agents in the spirocyclopropylcyclohexadienone (SCPCHD) family, which includes the duocarmycins, CC-1065, gilvusmycin, and yatakemycin. The yatakemycin biosynthesis cluster in Streptomyces sp. TP-A0356 contains an AlkD-related DNA glycosylase, YtkR2, that serves as a self-resistance mechanism against yatakemycin toxicity. We previously reported that AlkD, which is not present in an SCPCHD producer, provides only limited resistance against yatakemycin. We now show that YtkR2 and C10R5, a previously uncharacterized homolog found in the CC-1065 biosynthetic gene cluster of Streptomyces zelensis, confer far greater resistance against their respective SCPCHD natural products. We identify a structural basis for substrate specificity across gene clusters and show a correlation between in vivo resistance and in vitro enzymatic activity indicating that reduced product affinity-not enhanced substrate recognition-is the evolutionary outcome of selective pressure to provide self-resistance against yatakemycin and CC-1065.
2. Gilvusmycin, a new antitumor antibiotic related to CC-1065
Y Tokoro, T Isoe, K Shindo J Antibiot (Tokyo). 1999 Mar;52(3):263-8. doi: 10.7164/antibiotics.52.263.
A new antitumor antibiotic gilvusmycin was isolated from the culture broth of Streptomyces sp. QM16. The structure of gilvusmycin was related to CC-1065 and determined by NMR spectral analysis. Gilvusmycin exhibited antitumor activity against murine leukemia P388 in vivo.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
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