Grahamimycin B
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| Category | Antibiotics |
| Catalog number | BBF-01276 |
| CAS | 75979-94-1 |
| Molecular Weight | 300.30 |
| Molecular Formula | C14H20O7 |
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Description
It is produced by the strain of Cytospora sp. W. F. P. L. 13A (ATCC20502). It has weak activity against gram-positive bacteria, negative bacteria, cyanobacteria and green algae.
Specification
| Synonyms | 1,7-Dioxacyclotetradec-3-ene-2,8,11-trione,9,12-dihydroxy-6,14-dimethyl-, (6R-(3E,6R*,9R*,12R*,14S*))- |
| IUPAC Name | (3Z,6R,9R,12R,14S)-9,12-dihydroxy-6,14-dimethyl-1,7-dioxacyclotetradec-3-ene-2,8,11-trione |
| Canonical SMILES | CC1CC=CC(=O)OC(CC(C(=O)CC(C(=O)O1)O)O)C |
| InChI | InChI=1S/C14H20O7/c1-8-4-3-5-13(18)20-9(2)6-10(15)11(16)7-12(17)14(19)21-8/h3,5,8-10,12,15,17H,4,6-7H2,1-2H3/b5-3-/t8-,9+,10-,12-/m1/s1 |
| InChI Key | UPKYFPVASUJJTL-NZRRVRCFSA-N |
Properties
| Appearance | Colorless Acicular Crystal |
| Antibiotic Activity Spectrum | Gram-positive bacteria; Gram-negative bacteria |
| Boiling Point | 584.3 °C at 760 mmHg |
| Melting Point | 126-127 °C |
| Density | 1.214 g/cm3 |
| Solubility | Soluble in Chloroform |
Reference Reading
1. Grahamimycins: antibiotics from Cytospora sp. Ehrenb. W.F.P.L. 13A
S Gurusiddaiah, R C Ronald Antimicrob Agents Chemother. 1981 Jan;19(1):153-65. doi: 10.1128/AAC.19.1.153.
Aerobic fermentation of cultures of Cytospora sp. Ehrenb. W.F.P.L. 13A produces a group of novel, broad-spectrum, dilactone, macrocyclic antibiotics. These compounds, named grahamimycins, were isolated from the culture medium by extraction with organic solvents and separated by chromatography. Three active components have been obtained in crystalline form and have been designated grahamimycins A, A1, and B. The most active of these, grahamimycin A, exhibited activity against 36 species of bacteria, 8 species of blue-green algae (cyanobacteria), and 2 species of green algae, and antifungal activity against 5 fungi. Studies on the growth of the Cytospora with respect to formation of antibiotic activity, and the isolation, characterization, and structure elucidation of the grahamimycins are described. These studies indicate that the grahamimycins are distinct from other known antibiotics and represent a new class of antibiotic structures.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
