Halxazone
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
| Category | Others |
| Catalog number | BBF-01314 |
| CAS | |
| Molecular Weight | 257.24 |
| Molecular Formula | C14H11NO4 |
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Description
It is produced by the strain of Streptomyces halstedii 4029-SVS1. It is a substance that protects nerve cells. It protects PC12 cells from L-DOPA (50 X 10-6 mol/L) toxicity, and EG50 is 15.4 nmol/L. It also protects N18-RE105 cells from L-glutamate toxicity, and EG50 is 19.1 nmol/L.
Specification
| Synonyms | 1-Methoxy-8-hydroxy-methyl-3H-phenoxazin-3-one |
| IUPAC Name | 8-(hydroxymethyl)-1-methoxyphenoxazin-3-one |
| Canonical SMILES | COC1=CC(=O)C=C2C1=NC3=C(O2)C=CC(=C3)CO |
| InChI | InChI=1S/C14H11NO4/c1-18-12-5-9(17)6-13-14(12)15-10-4-8(7-16)2-3-11(10)19-13/h2-6,16H,7H2,1H3 |
| InChI Key | KLCVQEAOBBHOHH-UHFFFAOYSA-N |
Properties
| Melting Point | 201-202 °C |
| Solubility | Soluble in Methanol |
Reference Reading
1. Effect of medetomidine on respiration and minimum alveolar concentration in halothane- and isoflurane-anesthetized dogs
Phillip Lerche, William W Muir Am J Vet Res. 2006 May;67(5):782-9. doi: 10.2460/ajvr.67.5.782.
Objective: To evaluate the effect of medetomidine on minimum alveolar concentration (MAC), respiratory rate, tidal volume, minute volume (V(M)), and maximum inspiratory occlusion pressure (IOCP(max)) in halothane- and isoflurane-anesthetized dogs. Animals: 6 healthy adult dogs (3 males and 3 females). Procedure: The MAC of both inhalants was determined before and 5, 30, and 60 minutes after administration of medetomidine (5 microg/kg, IV). Dogs were subsequently anesthetized by administration of halothane or isoflurane and administered saline (0.9% NaCl) solution IV or medetomidine (5 microg/kg, IV). Respiratory variables and IOCP(max) were measured at specific MAC values 15 minutes before and 5, 30, and 60 minutes after IV administration of medetomidine while dogs breathed 0% and 10% fractional inspired carbon dioxide (FICO2). Slopes of the lines for VM/FICO2 and IOCP(max)/FICO2 were then calculated. Results: Administration of medetomidine decreased MAC of both inhalants. Slope of V(M)/FICO2 increased in dogs anesthetized with halothane after administration of medetomidine, compared with corresponding values in dogs anesthetized with isoflurane. Administration of medetomidine with a simultaneous decrease in inhalant concentration significantly increased the slope for V(M)/FICO2, compared with values after administration of saline solution in dogs anesthetized with halothane but not isoflurane. Values for IOCP(max) did not differ significantly between groups. Conclusions and clinical relevance: Equipotent doses of halothane and isoflurane have differing effects on respiration that are most likely attributable to differences in drug effects on central respiratory centers. Relatively low doses of medetomidine decrease the MAC of halothane and isoflurane in dogs.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
