Harzialactone B
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| Category | Antibiotics |
| Catalog number | BBF-03743 |
| CAS | |
| Molecular Weight | 142.15 |
| Molecular Formula | C7H10O3 |
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Description
It is produced by the strain of Trichoderma harzianum OUPS-N115. Harzialacton B has weak cytotoxicity to P388 leukemia cells with ED50 of 60 μg/mL.
Specification
| Synonyms | (4R)-4-Hydroxy-4-vinyltétrahydro-2H-pyran-2-one; 2H-Pyran-2-one, 4-ethenyltetrahydro-4-hydroxy-, (4R)-; (R)-4-hydroxy-4-vinyltetrahydro-2H-pyran-2-one |
| IUPAC Name | (4R)-4-ethenyl-4-hydroxyoxan-2-one |
| Canonical SMILES | C=CC1(CCOC(=O)C1)O |
| InChI | InChI=1S/C7H10O3/c1-2-7(9)3-4-10-6(8)5-7/h2,9H,1,3-5H2/t7-/m1/s1 |
| InChI Key | NMISCWYXUUBUIR-SSDOTTSWSA-N |
Properties
| Appearance | Colorless Oily Matter |
| Antibiotic Activity Spectrum | Neoplastics (Tumor) |
| Boiling Point | 283.3±40.0°C at 760 mmHg |
| Density | 1.3±0.1 g/cm3 |
| Solubility | Soluble in Ethanol, Chloroform |
Reference Reading
1. Cytotoxic substances produced by a fungal strain from a sponge: physico-chemical properties and structures
T Amagata, Y Usami, K Minoura, T Ito, A Numata J Antibiot (Tokyo). 1998 Jan;51(1):33-40. doi: 10.7164/antibiotics.51.33.
Five novel metabolites, trichodenones A-C (1-3), harzialactone A (4) and B (5), have been isolated together with known R-mevalonolactone (6) from the culture broth of a strain of Trichoderma harzianum OUPS-N115 originally separated from the sponge Halichondria okadai. Their structures have been elucidated by spectral evidence. Among them, 1-3 exhibited significant cytotoxicity against cultured P388 cells.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
