Harziphilone
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
| Category | Antibiotics |
| Catalog number | BBF-01323 |
| CAS | 183239-75-0 |
| Molecular Weight | 262.30 |
| Molecular Formula | C15H18O4 |
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Description
It is produced by the strain of Trichoderma harzianum. It has weak anti-gram-positive bacterial activity and anti-tumor effect, it can inhibit lymphoblastic leukemia L1210 and leukemia P388 with IC50 of 0.26 μg/mL. It inhibits the binding of viral particle regulatory (REV) proteins to [33P] labeled viral particle regulatory effector element (RRE) RNA, IC50 is 2.0 μmol/L. 200 μg/mL of Harziphilone does not protect CEM-SS cells from HIV-1 infection, and 38μmol/L of Harziphilone has cytotoxicity to mouse tumor cells M-109.
Specification
| Synonyms | rel-(6R,7R)-6,7-dihydroxy-7-methyl-3-[(1E,3E)-penta-1,3-dien-1-yl]-1,5,6,7-tetrahydro-8H-isochromen-8-one; (+)-Harziphilone; 8H-2-Benzopyran-8-one,1,5,6,7-tetrahydro-6,7-dihydroxy-7-methyl-3-(1E,3E)-1,3-pentadienyl-, (6R,7R)-rel- |
| IUPAC Name | (6R,7R)-6,7-dihydroxy-7-methyl-3-[(1E,3E)-penta-1,3-dienyl]-5,6-dihydro-1H-isochromen-8-one |
| Canonical SMILES | CC=CC=CC1=CC2=C(CO1)C(=O)C(C(C2)O)(C)O |
| InChI | InChI=1S/C15H18O4/c1-3-4-5-6-11-7-10-8-13(16)15(2,18)14(17)12(10)9-19-11/h3-7,13,16,18H,8-9H2,1-2H3/b4-3+,6-5+/t13-,15-/m1/s1 |
| InChI Key | GFTDIFRKHSPLIX-VNLWOOSYSA-N |
Properties
| Appearance | Orange Powder |
| Antibiotic Activity Spectrum | Gram-positive bacteria; Neoplastics (Tumor); Viruses |
| Boiling Point | 473.4 °C at 760 mmHg |
| Density | 1.24 g/cm3 |
| Solubility | Soluble in Methanol |
Reference Reading
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
