Hatomamicin
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| Category | Antibiotics |
| Catalog number | BBF-01324 |
| CAS | 116290-93-8 |
| Molecular Weight | 389.49 |
| Molecular Formula | C22H31NO5 |
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Description
It is produced by the strain of Saccharopolyspora YL-0358M. It is an alkaloid antibiotic. It has weaker activity against gram-positive bacteria. It also shows cytotoxicity to lymphocytic leukemia L1210 and leukemia P388 cells.
Specification
| Synonyms | Antibiotic YL-0358M-A |
| IUPAC Name | (2R,3R,6S)-6-[(Z,1E,4R,5S)-5-hydroxy-2-methyl-1-[(1R,3S)-2-oxa-6-azatricyclo[5.3.0.01,3]deca-6,8-dien-10-ylidene]hept-2-en-4-yl]oxy-2-methyloxan-3-ol |
| Canonical SMILES | CCC(C(C=C(C)C=C1C=CC2=NCCC3C12O3)OC4CCC(C(O4)C)O)O |
| InChI | InChI=1S/C22H31NO5/c1-4-16(24)18(27-21-8-6-17(25)14(3)26-21)12-13(2)11-15-5-7-19-22(15)20(28-22)9-10-23-19/h5,7,11-12,14,16-18,20-21,24-25H,4,6,8-10H2,1-3H3/b13-12-,15-11+/t14-,16+,17-,18-,20+,21+,22-/m1/s1 |
| InChI Key | YYNGBCGFVNIEML-ARHWDDMQSA-N |
Properties
| Appearance | Light Yellow Flaky Crystal |
| Antibiotic Activity Spectrum | Gram-positive bacteria; Neoplastics (Tumor) |
| Boiling Point | 595.3 °C at 760 mmHg |
| Melting Point | 93 °C |
| Density | 1.32 g/cm3 |
| Solubility | Soluble in Methanol, Acetone, Acetonitrile, Ethyl Acetate, Chloroform; Poorly soluble in Benzene |
Reference Reading
1. Hatomamicin (YL-0358M-A), a new alkaloid antibiotic: fermentation, isolation, structure, and biological properties
H Imai, S Fujita, K Suzuki, M Morioka, T Tokunaga, M Shimizu, S Kadota, T Furuya, T Saito J Antibiot (Tokyo). 1989 Jul;42(7):1043-8. doi: 10.7164/antibiotics.42.1043.
Hatomamicin, a new alkaloid antibiotic, was isolated from the culture filtrate of a strain of Saccharopolyspora. The antibiotic was extracted with EtOAc and purified by silica gel column chromatography. The free alkaloid was obtained as pale yellowish prisms from CH3CN solution. It exhibits antimicrobial activity against Gram-positive organisms. The apparent molecular formula of hatomamicin was determined to be C22H31NO5. The structure has been established by a combination of spectroscopic and X-ray crystallographic studies.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
