Hemipyocyanine
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| Category | Antibiotics |
| Catalog number | BBF-01814 |
| CAS | 528-71-2 |
| Molecular Weight | 196.21 |
| Molecular Formula | C12H8N2O |
| Purity | >95% |
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Description
Hemipyocyanine, an α-Amylase inhibitor, is produced by the strain of Pseudomonas aeruginosa. It has anti-gram-positive bacteria, negative-bacteria, trichophyta, yeast and other fungi activities.
Specification
| Synonyms | 1-Hydroxyphenazine; 1-Phenazinol; Pyoxanthose; NSC 88882; Phenazine, 1-hydroxy-; 1-Hydroxy-5,10-diazaanthracene; 5H-phenazin-1-one; alpha-Hydroxyphenazine; 1-Hydroxy-9,10-diazaanthracene; Hemipyocyanin; Pyoxanthose; α-Hydroxyphenazine |
| Storage | Store at -20°C |
| IUPAC Name | phenazin-1-ol |
| Canonical SMILES | C1=CC=C2C(=C1)N=C3C=CC=C(C3=N2)O |
| InChI | InChI=1S/C12H8N2O/c15-11-7-3-6-10-12(11)14-9-5-2-1-4-8(9)13-10/h1-7,15H |
| InChI Key | SVRNCBGWUMMBQB-UHFFFAOYSA-N |
| Source | Pseudomonas aeruginosa |
Properties
| Appearance | Yellow Ribbed Crystal |
| Antibiotic Activity Spectrum | Gram-positive bacteria; Gram-negative bacteria; Fungi; Yeast |
| Boiling Point | 430.0±10.0°C at 760 mmHg |
| Melting Point | 158°C |
| Density | 1.376±0.06 g/cm3 |
| Solubility | Soluble in DMF, DMSO, Ethanol, Methanol, Water (Poorly) |
Reference Reading
1. Novel α-Amylase Inhibitor Hemi-Pyocyanin Produced by Microbial Conversion of Chitinous Discards
Van Bon Nguyen, San-Lang Wang, Thi Hanh Nguyen, Thi Ngoc Tran, Chien Thang Doan, Anh Dzung Nguyen, Manh Dung Doan Mar Drugs . 2022 Apr 23;20(5):283. doi: 10.3390/md20050283.
α-Amylase inhibitors (aAIs) have been applied for the efficient management of type 2 diabetes. The aim of this study was to search for potential aAIs produced by microbial fermentation. Among various bacterial strains,Pseudomonas aeruginosaTUN03 was found to be a potential aAI-producing strain, and shrimp heads powder (SHP) was screened as the most suitable C/N source for fermentation.P. aeruginosaTUN03 exhibited the highest aAIs productivity (3100 U/mL) in the medium containing 1.5% SHP with an initial pH of 7-7.5, and fermentation was performed at 27.5 °C for two days. Further, aAI compounds were investigated for scaled-up production in a 14 L-bioreactor system. The results revealed a high yield (4200 U/mL) in a much shorter fermentation time (12 h) compared to fermentation in flasks. Bioactivity-guided purification resulted in the isolation of one major target compound, identified as hemi-pyocyanin (HPC) via gas chromatography-mass spectrometry and nuclear magnetic resonance. Its purity was analyzed by high-performance liquid chromatography. HPC demonstrated potent α-amylase inhibitory activity comparable to that of acarbose, a commercial antidiabetic drug. Notably, HPC was determined as a new aAI. The docking study indicated that HPC inhibits α-amylase by binding to amino acid Arg421 at the biding site on enzyme α-amylase with good binding energy (-9.3 kcal/mol) and creating two linkages of H-acceptors.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
