Herbimycin B
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| Category | Antibiotics |
| Catalog number | BBF-01343 |
| CAS | 76207-83-5 |
| Molecular Weight | 530.61 |
| Molecular Formula | C28H38N2O8 |
| Purity | ≥95% |
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Description
It is produced by the strain of Streptomyces hygroscopicus. It is an ansamycin antibiotic that acts as a Src family kinase inhibitor. It has herbicidal effect on most monocotyledons and dicotyledons, inhibits the activity of tobacco Mosaic virus (TMV), HeLa cells and Ehrlich cells.
Specification
| Synonyms | Geldanamycin, 17-demethoxy- |
| Storage | -20 °C |
| IUPAC Name | [(4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl] carbamate |
| Canonical SMILES | CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C=C(C1)C2=O)C)OC)OC(=O)N)C)C)O)OC |
| InChI | InChI=1S/C28H38N2O8/c1-15-10-19-13-20(31)14-21(25(19)33)30-27(34)16(2)8-7-9-22(36-5)26(38-28(29)35)18(4)12-17(3)24(32)23(11-15)37-6/h7-9,12-15,17,22-24,26,32H,10-11H2,1-6H3,(H2,29,35)(H,30,34)/b9-7-,16-8+,18-12+/t15-,17+,22+,23+,24-,26+/m1/s1 |
| InChI Key | ZRACUXWBSYZVLW-LCXCNHHZSA-N |
Properties
| Appearance | Yellow Crystal |
| Antibiotic Activity Spectrum | Neoplastics (Tumor); Viruses |
| Boiling Point | 756.8 °C at 760 mmHg |
| Melting Point | 220 °C (dec.) |
| Density | 1.22 g/cm3 |
| Solubility | Soluble in Methanol, Chloroform |
Reference Reading
1. Herbimycin B, a new benzoquinonoid ansamycin with anti-TMV and herbicidal activities
Y Iwai, A Nakagawa, N Sadakane, S Omura, H Oiwa, S Matsumoto, M Takahashi, T Ikai, Y Ochiai J Antibiot (Tokyo). 1980 Oct;33(10):1114-9. doi: 10.7164/antibiotics.33.1114.
A new benzoquinonoid ansamycin, herbimycin B was isolated from the culture broth of Streptomyces hygroscopicus No. AM-3672, a herbimycin A-producing strain. Herbimycin B showed potent anti-TMV activity. Herbicidal effect of herbimycin B was less than that of herbimycin A.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
