Hexacyclinol
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Category | Others |
Catalog number | BBF-00951 |
CAS | |
Molecular Weight | 416.47 |
Molecular Formula | C23H28O7 |
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Description
Hexacycline is a natural metabolite of the fungus Panus rudis HKI 0254. It has moderate anti-Gram-positive bacteria activity, 4-40μg/mL can inhibit the production of oxidants by polymorphonuclear neutrophils (PMNL) stimulated by zymosan. It inhibits the growth of L-930 and K 562 cells with IC50 of 1.4μg/mL and 0.4μg/mL, respectively, and the IC50 of HeLa cells is 10μg/mL. It also has an anti-Plasmodium effect, and its IC50 for Plasmodium falciparum is 2.4μg/mL.
Specification
Synonyms | (+)-Hexacyclinol |
IUPAC Name | (1S,2S,6S,8S,9R,10S,11S,12R,13S,15S,17R)-9-hydroxy-2-(2-methoxypropan-2-yl)-17-(2-methylprop-1-enyl)-7,14,18-trioxahexacyclo[10.4.2.01,11.04,10.06,8.013,15]octadec-3-ene-5,16-dione |
Canonical SMILES | CC(=CC1C23C(C=C4C(C2C(O1)C5C(C3=O)O5)C(C6C(C4=O)O6)O)C(C)(C)OC)C |
InChI | InChI=1S/C23H28O7/c1-8(2)6-11-23-10(22(3,4)27-5)7-9-12(15(25)18-17(29-18)14(9)24)13(23)16(28-11)19-20(30-19)21(23)26/h6-7,10-13,15-20,25H,1-5H3/t10-,11-,12-,13-,15-,16-,17-,18+,19+,20+,23+/m1/s1 |
InChI Key | PFZFRWWDGXFULQ-NHFKQXEKSA-N |
Properties
Appearance | Colorless Solid |
Antibiotic Activity Spectrum | Gram-positive bacteria |
Boiling Point | 615.5±55.0 °C at 760 mmHg |
Melting Point | 172-173°C |
Density | 1.4±0.1 g/cm3 |
Reference Reading
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2