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Hydroxyakalone

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Category Enzyme inhibitors
Catalog number BBF-00986
CAS 182056-35-5
Molecular Weight 167.13
Molecular Formula C5H5N5O2

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Fermentation Lab

4 R&D and scale-up labs

2 Preparative purification labs

Fermentation Plant

Semi pilot, pilot and industrial plant 4 Manufacturing sites 7 Production lines at pilot scale 100+ Reactors of 30-4000 L; 170+ reactors of 20 KL-30 KL; 24+ reactors of >100 KL 2 Hydrogenation reactors (200 L, 4Mpa and 1000L, 4Mpa)

Product Description

Hydroxyakalone is an inhibitor of Xanthosine oxidase (XOD, EC 1.2.3.2) produced by Agrobacterium aurantiacumn N81106. It inhibits XOD with an IC50 of 4.6 μmol/L, which is stronger than acathone (IC50 16.9 μmol/L).

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Synonyms 1h-pyrazolo[3,4-d]pyrimidine-3,6(2h,7h)-dione,4-amino-
IUPAC Name 4-amino-2,5-dihydro-1H-pyrazolo[3,4-d]pyrimidine-3,6-dione
Canonical SMILES C12=C(NC(=O)N=C1NNC2=O)N
InChI InChI=1S/C5H5N5O2/c6-2-1-3(8-5(12)7-2)9-10-4(1)11/h(H5,6,7,8,9,10,11,12)
InChI Key KHPWHSXHIVVNRI-UHFFFAOYSA-N
Appearance Colorless Powder
Density 2.5±0.1 g/cm3
1. Hydroxyakalone, a novel xanthine oxidase inhibitor produced by a marine bacterium, Agrobacterium aurantiacum
H Izumida, K Adachi, A Mihara, T Yasuzawa, H Sano J Antibiot (Tokyo). 1997 Nov;50(11):916-8. doi: 10.7164/antibiotics.50.916.
A new xanthine oxidase inhibitor named hydroxyakalone was isolated from the culture broth of a marine bacterium Agrobacterium aurantiacum N-81106. Structure of hydroxyakalone was determined to be 4-amino-1H-pyrazolo[3,4-d]pyrimidine-3-one-6-ol by the spectral studies of hydroxyakalone and its permethyl derivative. The concentration to induce 50% inhibition (IC50) was 4.6 microM against xanthine oxidase.

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Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2

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Tip: Chemical formula is case sensitive. C22H30N4O c22h30n40
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