Hydroxyakalone
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| Category | Enzyme inhibitors |
| Catalog number | BBF-00986 |
| CAS | 182056-35-5 |
| Molecular Weight | 167.13 |
| Molecular Formula | C5H5N5O2 |
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Description
Hydroxyakalone is an inhibitor of Xanthosine oxidase (XOD, EC 1.2.3.2) produced by Agrobacterium aurantiacumn N81106. It inhibits XOD with an IC50 of 4.6 μmol/L, which is stronger than acathone (IC50 16.9 μmol/L).
Specification
| Synonyms | 1h-pyrazolo[3,4-d]pyrimidine-3,6(2h,7h)-dione,4-amino- |
| IUPAC Name | 4-amino-2,5-dihydro-1H-pyrazolo[3,4-d]pyrimidine-3,6-dione |
| Canonical SMILES | C12=C(NC(=O)N=C1NNC2=O)N |
| InChI | InChI=1S/C5H5N5O2/c6-2-1-3(8-5(12)7-2)9-10-4(1)11/h(H5,6,7,8,9,10,11,12) |
| InChI Key | KHPWHSXHIVVNRI-UHFFFAOYSA-N |
Properties
| Appearance | Colorless Powder |
| Density | 2.5±0.1 g/cm3 |
Reference Reading
1. Hydroxyakalone, a novel xanthine oxidase inhibitor produced by a marine bacterium, Agrobacterium aurantiacum
H Izumida, K Adachi, A Mihara, T Yasuzawa, H Sano J Antibiot (Tokyo). 1997 Nov;50(11):916-8. doi: 10.7164/antibiotics.50.916.
A new xanthine oxidase inhibitor named hydroxyakalone was isolated from the culture broth of a marine bacterium Agrobacterium aurantiacum N-81106. Structure of hydroxyakalone was determined to be 4-amino-1H-pyrazolo[3,4-d]pyrimidine-3-one-6-ol by the spectral studies of hydroxyakalone and its permethyl derivative. The concentration to induce 50% inhibition (IC50) was 4.6 microM against xanthine oxidase.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
