Hydroxymycotrienin B
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| Category | Antibiotics |
| Catalog number | BBF-01015 |
| CAS | 178550-62-4 |
| Molecular Weight | 652.77 |
| Molecular Formula | C36H48N2O9 |
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Description
Hydroxymycotrienin B is an Ansa antibiotic produced by Bacillus sp. BMJ958-62F4. It has the activity of inhibiting human neck tumor cell line, and its inhibitory effect on human papillomavirus (HPV) gene positive neck tumor cells (such as HeLa, CaSki, SiHa, etc.) is stronger than HPV gene negative cells.
Specification
| IUPAC Name | (6Z,8Z,10Z,16Z,20E)-13,24-dihydroxy-5-methoxy-14,16-dimethyl-3,21,22-trioxo-2-azabicyclo[18.3.1]tetracosa-1(23),6,8,10,16,20(24)-hexaen-15-yl (cyclohexanecarbonyl)-D-alaninate |
Properties
| Appearance | Brown Powder |
| Antibiotic Activity Spectrum | neoplastics (Tumor) |
Reference Reading
1. Hydroxymycotrienins A and B, new ansamycin group antibiotics
N Hosokawa, H Naganawa, M Hamada, T Takeuchi, S Ikeno, M Hori J Antibiot (Tokyo). 1996 May;49(5):425-31. doi: 10.7164/antibiotics.49.425.
New ansamycins designated hydroxymycotrienins A and B were isolated from culture broths of Bacillus sp. BMJ958-62F4. The two antibiotics inhibited more strongly the growth of human cervical cancer cell lines of human papilloma virus (HPV) positive than that of HPV negative cell lines. The structures, some biological and biochemical properties are reported.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
