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IC202B

* Please be kindly noted products are not for therapeutic use. We do not sell to patients.

Category Antibiotics
Catalog number BBF-03592
CAS
Molecular Weight 532.63
Molecular Formula C23H44N6O8

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Capabilities & Facilities

Fermentation Lab

4 R&D and scale-up labs

2 Preparative purification labs

Fermentation Plant

Semi pilot, pilot and industrial plant 4 Manufacturing sites 7 Production lines at pilot scale 100+ Reactors of 30-4000 L; 170+ reactors of 20 KL-30 KL; 24+ reactors of >100 KL 2 Hydrogenation reactors (200 L, 4Mpa and 1000L, 4Mpa)

Product Description

IC202B shows immunosuppressive activity, with IC50 of 3.6 μg/mL as determined by MLCR, and has a strong inhibitory effect on Blastogensis induced by ConA or lipopolysaccharide (LPS).

  • Specification
  • Properties
  • Reference Reading
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Synonyms N-(5-aminopentyl)-N-hydroxy-N'-[5-(hydroxy{4-[(5-nitropentyl)amino]-4-oxobutanoyl}amino)pentyl]butanediamide; IC-202B
IUPAC Name N'-(5-aminopentyl)-N'-hydroxy-N-[5-[hydroxy-[4-(5-nitropentylamino)-4-oxobutanoyl]amino]pentyl]butanediamide
Canonical SMILES C(CCN)CCN(C(=O)CCC(=O)NCCCCCN(C(=O)CCC(=O)NCCCCC[N+](=O)[O-])O)O
InChI InChI=1S/C23H44N6O8/c24-14-4-1-7-17-27(34)22(32)12-10-20(30)25-15-5-2-8-18-28(35)23(33)13-11-21(31)26-16-6-3-9-19-29(36)37/h34-35H,1-19,24H2,(H,25,30)(H,26,31)
InChI Key BHNYEXHOBOECJW-UHFFFAOYSA-N
Appearance Pale Yellow Powder
Melting Point 117-119°C
1. IC202B and C, new siderophores with immunosuppressive activity produced by Streptoalloteichus sp. 1454-19
M Iijima, T Someno, M Ishizuka, R Sawa, H Naganawa, T Takeuchi J Antibiot (Tokyo). 1999 Sep;52(9):775-80. doi: 10.7164/antibiotics.52.775.
IC202B (1) and C (2) were isolated from the culture filtrate of Streptoalloteichus sp. 1454-19. The structures were elucidated by various NMR spectral analyses including 1H-15N HMBC and FAB-MS experiments. IC202B and C showed immunosuppressive activity on a mixed lymphocyte culture reaction at the same IC50 value of 1.6 microg/ml.

Bio Calculators

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L

* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2

* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O c22h30n40
g/mol
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