IC202B
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| Category | Antibiotics |
| Catalog number | BBF-03592 |
| CAS | |
| Molecular Weight | 532.63 |
| Molecular Formula | C23H44N6O8 |
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Description
IC202B shows immunosuppressive activity, with IC50 of 3.6 μg/mL as determined by MLCR, and has a strong inhibitory effect on Blastogensis induced by ConA or lipopolysaccharide (LPS).
Specification
| Synonyms | N-(5-aminopentyl)-N-hydroxy-N'-[5-(hydroxy{4-[(5-nitropentyl)amino]-4-oxobutanoyl}amino)pentyl]butanediamide; IC-202B |
| IUPAC Name | N'-(5-aminopentyl)-N'-hydroxy-N-[5-[hydroxy-[4-(5-nitropentylamino)-4-oxobutanoyl]amino]pentyl]butanediamide |
| Canonical SMILES | C(CCN)CCN(C(=O)CCC(=O)NCCCCCN(C(=O)CCC(=O)NCCCCC[N+](=O)[O-])O)O |
| InChI | InChI=1S/C23H44N6O8/c24-14-4-1-7-17-27(34)22(32)12-10-20(30)25-15-5-2-8-18-28(35)23(33)13-11-21(31)26-16-6-3-9-19-29(36)37/h34-35H,1-19,24H2,(H,25,30)(H,26,31) |
| InChI Key | BHNYEXHOBOECJW-UHFFFAOYSA-N |
Properties
| Appearance | Pale Yellow Powder |
| Melting Point | 117-119°C |
Reference Reading
1. IC202B and C, new siderophores with immunosuppressive activity produced by Streptoalloteichus sp. 1454-19
M Iijima, T Someno, M Ishizuka, R Sawa, H Naganawa, T Takeuchi J Antibiot (Tokyo). 1999 Sep;52(9):775-80. doi: 10.7164/antibiotics.52.775.
IC202B (1) and C (2) were isolated from the culture filtrate of Streptoalloteichus sp. 1454-19. The structures were elucidated by various NMR spectral analyses including 1H-15N HMBC and FAB-MS experiments. IC202B and C showed immunosuppressive activity on a mixed lymphocyte culture reaction at the same IC50 value of 1.6 microg/ml.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
