Imbricaric acid
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| Category | Others |
| Catalog number | BBF-05411 |
| CAS | 491-57-6 |
| Molecular Weight | 416.46 |
| Molecular Formula | C23H28O7 |
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Specification
| Synonyms | Benzoic acid, 2-hydroxy-4-[(2-hydroxy-4-methoxy-6-pentylbenzoyl)oxy]-6-propyl-; Imbricarsaeure; 2-Hydroxy-4-(2-hydroxy-4-methoxy-6-pentyl-benzoyloxy)-6-propyl-benzoesaeure |
| IUPAC Name | 2-hydroxy-4-(2-hydroxy-4-methoxy-6-pentylbenzoyl)oxy-6-propylbenzoic acid |
| Canonical SMILES | CCCCCC1=C(C(=CC(=C1)OC)O)C(=O)OC2=CC(=C(C(=C2)O)C(=O)O)CCC |
| InChI | InChI=1S/C23H28O7/c1-4-6-7-9-15-10-16(29-3)12-19(25)21(15)23(28)30-17-11-14(8-5-2)20(22(26)27)18(24)13-17/h10-13,24-25H,4-9H2,1-3H3,(H,26,27) |
| InChI Key | QXDIHIOKSGGXLD-UHFFFAOYSA-N |
Properties
| Boiling Point | 595.4±50.0°C (Predicted) |
| Melting Point | 125-126°C |
| Density | 1.232±0.06 g/cm3 (Predicted) |
Reference Reading
1. Imbricaric acid and perlatolic acid: multi-targeting anti-inflammatory depsides from Cetrelia monachorum
Sarah K Oettl, Jana Gerstmeier, Shafaat Y Khan, Katja Wiechmann, Julia Bauer, Atanas G Atanasov, Clemens Malainer, Ezzat M Awad, Pavel Uhrin, Elke H Heiss, Birgit Waltenberger, Daniel Remias, Johannes M Breuss, Joel Boustie, Verena M Dirsch, Hermann Stuppner, Oliver Werz, Judith M Rollinger PLoS One. 2013 Oct 9;8(10):e76929. doi: 10.1371/journal.pone.0076929. eCollection 2013.
In vitro screening of 17 Alpine lichen species for their inhibitory activity against 5-lipoxygenase, microsomal prostaglandin E2 synthase-1 and nuclear factor kappa B revealed Cetrelia monachorum (Zahlbr.) W.L. Culb. & C.F. Culb. As conceivable source for novel anti-inflammatory compounds. Phytochemical investigation of the ethanolic crude extract resulted in the isolation and identification of 11 constituents, belonging to depsides and derivatives of orsellinic acid, olivetolic acid and olivetol. The two depsides imbricaric acid (4) and perlatolic acid (5) approved dual inhibitory activities on microsomal prostaglandin E2 synthase-1 (IC50 = 1.9 and 0.4 µM, resp.) and on 5-lipoxygenase tested in a cell-based assay (IC50 = 5.3 and 1.8 µM, resp.) and on purified enzyme (IC50 = 3.5 and 0.4 µM, resp.). Additionally, these two main constituents quantified in the extract with 15.22% (4) and 9.10% (5) showed significant inhibition of tumor necrosis factor alpha-induced nuclear factor kappa B activation in luciferase reporter cells with IC50 values of 2.0 and 7.0 µM, respectively. In a murine in vivo model of inflammation, 5 impaired the inflammatory, thioglycollate-induced recruitment of leukocytes to the peritoneum. The potent inhibitory effects on the three identified targets attest 4 and 5 a pronounced multi-target anti-inflammatory profile which warrants further investigation on their pharmacokinetics and in vivo efficacy.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
