Imipenem Monohydrate
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Category | Antibiotics |
Catalog number | BBF-04641 |
CAS | 74431-23-5 |
Molecular Weight | 317.36 |
Molecular Formula | C12H17N3O4S.H2O |
Purity | 98% |
Ordering Information
Catalog Number | Size | Price | Stock | Quantity |
---|---|---|---|---|
BBF-04641 | 500 mg | $199 | In stock |
Online Inquiry
Add to cartDescription
Imipenem is an intravenous β-lactam antibiotic. It is the first member of the carbapenem class of antibiotics. Imipenem is discovered via a lengthy trial-and-error search for a more stable version of the natural product thienamycin, which is produced by the bacterium Streptomyces cattleya. Imipenem has a broad spectrum of activity against aerobic and anaerobic, Gram-positive and Gram-negative bacteria. It is particularly important for its activity against Pseudomonas aeruginosa and the Enterococcus species, but it is not active against MRSA.
Specification
Related CAS | 64221-86-9 (anhydrous) |
Synonyms | (5R,6S)-6-[(1R)-1-hydroxyethyl]-3-[[2-[(iminomethyl)amino]ethyl]thio]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, monohydrate; N-Formimidoyl Thienamycin; MK-787; MK 787; MK787 |
Shelf Life | 3 years |
Storage | Store at -20°C |
IUPAC Name | (5R,6S)-3-[2-(aminomethylideneamino)ethylsulfanyl]-6-[(1R)-1-hydroxyethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid;hydrate |
Canonical SMILES | CC(C1C2CC(=C(N2C1=O)C(=O)O)SCCN=CN)O.O |
InChI | InChI=1S/C12H17N3O4S.H2O/c1-6(16)9-7-4-8(20-3-2-14-5-13)10(12(18)19)15(7)11(9)17;/h5-7,9,16H,2-4H2,1H3,(H2,13,14)(H,18,19);1H2/t6-,7-,9-;/m1./s1 |
InChI Key | GSOSVVULSKVSLQ-JJVRHELESA-N |
Properties
Appearance | Off-white to Pale Yellow Solid |
Application | Anti-Bacterial Agents |
Antibiotic Activity Spectrum | Gram-positive bacteria; Gram-negative bacteria |
Boiling Point | 567.3°C at 760 mmHg |
Melting Point | 193-198°C |
Solubility | Soluble in DMSO, Methanol |
Toxicity
Carcinogenicity | No indication of carcinogenicity to humans (not listed by IARC). |
Mechanism Of Toxicity | Imipenem acts as an antimicrobial through the inhibition of cell wall synthesis of various gram-positive and gram-negative bacteria. This inhibition of cell wall synthesis in gram-negative bateria is attained by binding to pencillin binding proteins (PBPs). In E. coli and selected strains of P. aeruginosa, imipenem has shown to have the highest affinity to PBP-2, PBP-1a, and PBP-1b. This preferential binding to PBP-2 and PBP-1b results in the direct conversion of the individual cell to a spheroblast, which leads to rapid cell lysis and death without filament formation. |
Reference Reading
Spectrum
Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive
Experimental Conditions
Ionization Energy: 70 eV
Chromatography Type: Gas Chromatography Column (GC)
Instrument Type: Single quadrupole, spectrum predicted by CFM-ID(EI)
Mass Resolution: 0.0001 Da
Molecular Formula: C12H17N3O4S
Molecular Weight (Monoisotopic Mass): 299.094 Da
Molecular Weight (Avergae Mass): 299.346 Da
Predicted LC-MS/MS Spectrum - 10V, Positive
Experimental Conditions
Collision Energy: 10 eV
Instrument Type: QTOF (generic), spectrum predicted by CFM-ID
Mass Resolution: 0.0001 Da
Molecular Formula: C12H17N3O4S
Molecular Weight (Monoisotopic Mass): 299.094 Da
Molecular Weight (Avergae Mass): 299.346 Da
1H NMR Spectrum
Experimental Conditions
Nucleus: 1H
Frequency: 100
Recommended Products
BBF-02577 | Pneumocandin C0 | Inquiry |
BBF-05853 | Palbociclib | Inquiry |
BBF-00969 | Homomycin | Inquiry |
BBF-05827 | Spliceostatin A | Inquiry |
BBF-03488 | Streptozotocin | Inquiry |
BBF-03816 | Milbemycin oxime | Inquiry |
Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2