Inactone

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Category Antibiotics
Catalog number BBF-01499
CAS 487-34-3
Molecular Weight 279.33
Molecular Formula C15H21NO4

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Description

Inactone is a bioactive molecule of 3-glutarimidyl group that inhibits large ribosomal subunit.

Specification

InChI Key GCCDDVHZHSSEMD-HOTUBEGUSA-N

Properties

Appearance Colorless Acicular Crystalline
Antibiotic Activity Spectrum fungi
Melting Point 116°C

Reference Reading

1. Subacute thyroiditis after inactive SARS-CoV-2 vaccine
Emre Sedar Saygılı, Ersen Karakilic BMJ Case Rep. 2021 Oct 1;14(10):e244711. doi: 10.1136/bcr-2021-244711.
Viral infections have often been associated with subacute (De Quervain) thyroiditis. Rare cases of subacute thyroiditis have been reported after vaccines. Various vaccines have been developed with different techniques against SARS-CoV-2. This case report presents a rare case of subacute thyroiditis after the inactive SARS-CoV-2 virus vaccine, CoronaVac.
2. Efficacy of Mobile Health Applications to Improve Physical Activity and Sedentary Behavior: A Systematic Review and Meta-Analysis for Physically Inactive Individuals
Meng Zhang, Wei Wang, Mingye Li, Haomin Sheng, Yifei Zhai Int J Environ Res Public Health. 2022 Apr 18;19(8):4905. doi: 10.3390/ijerph19084905.
Physical inactivity and sedentary behavior (SB) have attracted growing attention globally since they relate to noninfectious chronic diseases (NCDs) and could further result in the loss of life. This systematic literature review aimed to identify existing evidence on the efficacy of mobile health (mHealth) technology in inducing physical activity and reducing sedentary behavior for physically inactive people. Studies were included if they used a smartphone app in an intervention to improve physical activity and/or sedentary behavior for physically inactive individuals. Interventions could be stand-alone interventions or multi-component interventions, including an app as one of several intervention components. A total of nine studies were included, and all were randomized controlled trials. Two studies involved interventions delivered solely via a mobile application (stand-alone intervention) and seven studies involved interventions that used apps and other intervention strategies (multi-component intervention). Methodological quality was assessed, and the overall quality of the studies was ensured. The pooled data favored intervention in improving physical activity and reducing sedentary behavior. This review provided evidence that mobile health intervention improved physical activity and reduced sedentary behavior among inactive individuals. More beneficial effects can be guaranteed when interventions include multiple components. Further studies that maintain the effectiveness of such interventions are required to maximize user engagement and intervention efficacy.
3. Sedentary lifestyle a disease from xxi century
J Ildefonzo Arocha Rodulfo Clin Investig Arterioscler. 2019 Sep-Oct;31(5):233-240. doi: 10.1016/j.arteri.2019.04.004. Epub 2019 Jun 17.
Sedentarism and physical inactivity is highly prevalent globally, and are associated with a wide range of chronic diseases and premature deaths. The interest in sedentary behaviour is justified by a growing body of evidence that points to a relationship between this lifestyle and the increase in the prevalence of obesity, diabetes and cardiovascular disease. It has been known throughout history that being inactive is unhealthy, but nowadays almost one-third of the world's population is inactive, thus representing a major public health problem.

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