Isochromophilone V
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| Category | Enzyme inhibitors |
| Catalog number | BBF-01511 |
| CAS | 167355-56-8 |
| Molecular Weight | 350.84 |
| Molecular Formula | C19H23ClO4 |
| Purity | >98% |
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Description
Isochromophilone III is produced by the strain of Pen. multicolor FO-3216 and FO-2328. It inhibited the ACAT of rat hepatocellular microsome and the B-16 melanoma cell with the IC50 (μmol/L) of 50 and 36.
Specification
| Synonyms | 6H-2-Benzopyran-6-one, 5-chloro-3-(3,5-dimethyl-1,3-heptadienyl)-7,8-dihydro-7,8-dihydroxy-7-methyl |
| IUPAC Name | (7R,8R)-5-chloro-3-[(1E,3E,5S)-3,5-dimethylhepta-1,3-dienyl]-7,8-dihydroxy-7-methyl-8H-isochromen-6-one |
| Canonical SMILES | CCC(C)C=C(C)C=CC1=CC2=C(C(=O)C(C(C2=CO1)O)(C)O)Cl |
| InChI | InChI=1S/C19H23ClO4/c1-5-11(2)8-12(3)6-7-13-9-14-15(10-24-13)17(21)19(4,23)18(22)16(14)20/h6-11,17,21,23H,5H2,1-4H3/b7-6+,12-8+/t11-,17+,19+/m0/s1 |
| InChI Key | ZFOBGKZKFOAYTR-ZZSXOZOGSA-N |
Properties
| Appearance | Yellow Powder |
| Antibiotic Activity Spectrum | neoplastics (Tumor) |
| Boiling Point | 492.4°C at 760 mmHg |
| Melting Point | 58-61°C |
| Density | 1.25 g/cm3 |
Reference Reading
1. Isochromophilones III-VI, inhibitors of acyl-CoA:cholesterol acyltransferase produced by Penicillium multicolor FO-3216
N Arai, K Shiomi, H Tomoda, N Tabata, D J Yang, R Masuma, T Kawakubo, S Omura J Antibiot (Tokyo). 1995 Jul;48(7):696-702. doi: 10.7164/antibiotics.48.696.
New azaphilones named isochromophilones III-VI were isolated from the culture broth of Penicillium multicolor FO-3216 as inhibitors of acyl-CoA: cholesterol acyltransferase (ACAT). Their structures were elucidated by NMR and other spectroscopic analyses. The IC50 values of isochromophilones III, IV, V and VI for ACAT activity in an enzyme assay using rat liver microsomes were calculated to be 110, 50, 50 and 120 microM, respectively.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
