Isoleucyl-threonine
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| Category | Others |
| Catalog number | BBF-05476 |
| CAS | 59652-61-8 |
| Molecular Weight | 232.28 |
| Molecular Formula | C10H20N2O4 |
| Purity | ≥95% |
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Description
Isoleucyl-threonine is a dipeptide composed of isoleucine and threonine. It is an incomplete breakdown product of protein digestion or protein catabolism.
Specification
| Synonyms | H-IT-OH; L-isoleucyl-L-threonine; IT dipeptide; Ile-Thr; L-Threonine, L-isoleucyl-; N-L-isoleucyl-L-Threonine |
| Sequence | H-Ile-Thr-OH |
| IUPAC Name | (2S,3R)-2-[[(2S,3S)-2-amino-3-methylpentanoyl]amino]-3-hydroxybutanoic acid |
| Canonical SMILES | CCC(C)C(C(=O)NC(C(C)O)C(=O)O)N |
| InChI | InChI=1S/C10H20N2O4/c1-4-5(2)7(11)9(14)12-8(6(3)13)10(15)16/h5-8,13H,4,11H2,1-3H3,(H,12,14)(H,15,16)/t5-,6+,7-,8-/m0/s1 |
| InChI Key | DRCKHKZYDLJYFQ-YWIQKCBGSA-N |
Properties
| Appearance | Solid |
| Boiling Point | 471.6±45.0°C at 760 mmHg |
| Density | 1.2±0.1 g/cm3 |
| Solubility | Soluble in Water |
Reference Reading
1. Metabolomics Profiling of Nephrotic Syndrome towards Biomarker Discovery
Minnie Jacob, Refat M Nimer, Mohamad S Alabdaljabar, Essa M Sabi, Mysoon M Al-Ansari, Maged Housien, Khalid M Sumaily, Lina A Dahabiyeh, Anas M Abdel Rahman Int J Mol Sci. 2022 Oct 20;23(20):12614. doi: 10.3390/ijms232012614.
Nephrotic syndrome (NS) is a kidney illness characterized by excessive proteinuria, hypoalbuminemia, edema, and hyperlipidemia, which may lead to kidney failure and necessitate renal transplantation. End-stage renal disease, cardiovascular issues, and mortality are much more common in those with NS. Therefore, the present study aimed to identify potential new biomarkers associated with the pathogenesis and diagnosis of NS. The liquid chromatography-mass spectrometry (LC-MS) metabolomics approach was applied to profile the metabolome of human serum of patients with NS. A total of 176 metabolites were significantly altered in NS compared to the control. Arginine, proline, and tryptophan metabolism; arginine, phenylalanine, tyrosine, and tryptophan biosynthesis were the most common metabolic pathways dysregulated in NS. Furthermore, alanyl-lysine and isoleucyl-threonine had the highest discrimination between NS and healthy groups. The candidate biomarkers may lead to understanding the possible metabolic alterations associated with NS and serve as potential diagnostic biomarkers.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
