IT-143-B

Name: IT-143-B
Brand: BOC Sciences
Rating: 5 (1 reviews)

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Category	Antibiotics
Catalog number	BBF-03596
CAS	183485-34-9
Molecular Weight	455.63
Molecular Formula	C28H41NO4
Purity	≥95%

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Fermentation Lab

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Semi pilot, pilot and industrial plant 4 Manufacturing sites 7 Production lines at pilot scale 100+ Reactors of 30-4000 L; 170+ reactors of 20 KL-30 KL; 24+ reactors of >100 KL 2 Hydrogenation reactors (200 L, 4Mpa and 1000L, 4Mpa)

Product Description

IT-143-B is produced by the strain of Streptomyces sp.IT-143. It has activity against individual gram-positive bacteria (Micrococcus gaminerae) and individual fungi (Aspergillus fumigatus). And it is also cytotoxic to KB cells.

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Synonyms	IT-143B
Storage	Store at -20°C
IUPAC Name	2-[(2E,5E,7E,11E,13E)-10-hydroxy-3,7,9,11,13-pentamethylpentadeca-2,5,7,11,13-pentaenyl]-5,6-dimethoxy-3-methyl-1H-pyridin-4-one
Canonical SMILES	CC=C(C)C=C(C)C(C(C)C=C(C)C=CCC(=CCC1=C(C(=O)C(=C(N1)OC)OC)C)C)O
InChI	InChI=1S/C28H41NO4/c1-10-18(2)16-21(5)25(30)22(6)17-20(4)13-11-12-19(3)14-15-24-23(7)26(31)27(32-8)28(29-24)33-9/h10-11,13-14,16-17,22,25,30H,12,15H2,1-9H3,(H,29,31)/b13-11+,18-10+,19-14+,20-17+,21-16+
InChI Key	QDBZGOIMALIBKV-JXOBDNEFSA-N

Appearance	Pale Yellow Oily Matter
Antibiotic Activity Spectrum	Gram-positive bacteria; neoplastics (Tumor); fungi
Boiling Point	628.8±55.0°C at 760 mmHg
Density	1.0±0.1 g/cm3
Solubility	Soluble in DMSO

1. A novel nuclear export inhibitor JBIR-02, a new piericidin discovered from Streptomyces sp. ML55

Kazuo Shin-Ya, Naoki Goshima, Aya Nagai, Yasutomo Kisu, Jun-Ya Ueda, Takuji Nakashima, Hisayuki Komaki, Takayuki Doi, Nobuo Nomura, Motoki Takagi, Shigeaki Harayama, Takushi Togashi, Kozue Anzai, Susumu Matukura, Tohru Natsume, Takashi Takahashi J Antibiot (Tokyo) . 2007 Jul;60(7):459-62. doi: 10.1038/ja.2007.59.

A new member of the piericidin family, JBIR-02, was isolated from mycelium of Streptomyces sp. ML55 together with two known piericidin derivatives, piericidin A(1) and IT-143-B. The structure was determined on the basis of spectroscopic data. JBIR-02 inhibited nuclear export of beta-arrestin in HeLa cells at the concentration of 20 microM.

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IT-143-B

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