IT-143-B
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| Category | Antibiotics |
| Catalog number | BBF-03596 |
| CAS | 183485-34-9 |
| Molecular Weight | 455.63 |
| Molecular Formula | C28H41NO4 |
| Purity | ≥95% |
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Description
IT-143-B is produced by the strain of Streptomyces sp.IT-143. It has activity against individual gram-positive bacteria (Micrococcus gaminerae) and individual fungi (Aspergillus fumigatus). And it is also cytotoxic to KB cells.
Specification
| Synonyms | IT-143B |
| Storage | Store at -20°C |
| IUPAC Name | 2-[(2E,5E,7E,11E,13E)-10-hydroxy-3,7,9,11,13-pentamethylpentadeca-2,5,7,11,13-pentaenyl]-5,6-dimethoxy-3-methyl-1H-pyridin-4-one |
| Canonical SMILES | CC=C(C)C=C(C)C(C(C)C=C(C)C=CCC(=CCC1=C(C(=O)C(=C(N1)OC)OC)C)C)O |
| InChI | InChI=1S/C28H41NO4/c1-10-18(2)16-21(5)25(30)22(6)17-20(4)13-11-12-19(3)14-15-24-23(7)26(31)27(32-8)28(29-24)33-9/h10-11,13-14,16-17,22,25,30H,12,15H2,1-9H3,(H,29,31)/b13-11+,18-10+,19-14+,20-17+,21-16+ |
| InChI Key | QDBZGOIMALIBKV-JXOBDNEFSA-N |
Properties
| Appearance | Pale Yellow Oily Matter |
| Antibiotic Activity Spectrum | Gram-positive bacteria; neoplastics (Tumor); fungi |
| Boiling Point | 628.8±55.0°C at 760 mmHg |
| Density | 1.0±0.1 g/cm3 |
| Solubility | Soluble in DMSO |
Reference Reading
1. A novel nuclear export inhibitor JBIR-02, a new piericidin discovered from Streptomyces sp. ML55
Kazuo Shin-Ya, Naoki Goshima, Aya Nagai, Yasutomo Kisu, Jun-Ya Ueda, Takuji Nakashima, Hisayuki Komaki, Takayuki Doi, Nobuo Nomura, Motoki Takagi, Shigeaki Harayama, Takushi Togashi, Kozue Anzai, Susumu Matukura, Tohru Natsume, Takashi Takahashi J Antibiot (Tokyo) . 2007 Jul;60(7):459-62. doi: 10.1038/ja.2007.59.
A new member of the piericidin family, JBIR-02, was isolated from mycelium of Streptomyces sp. ML55 together with two known piericidin derivatives, piericidin A(1) and IT-143-B. The structure was determined on the basis of spectroscopic data. JBIR-02 inhibited nuclear export of beta-arrestin in HeLa cells at the concentration of 20 microM.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
