Juvenimicin A2
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| Category | Antibiotics |
| Catalog number | BBF-01525 |
| CAS | 61417-47-8 |
| Molecular Weight | 553.73 |
| Molecular Formula | C30H51NO8 |
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Description
It is produced by the strain of Micromono spora chalcea var. izumensis. Juvenimicin A2 can resist gram-positive bacteria and individual gram-negative bacteria.
Specification
| Synonyms | BRN 1413776; 6-De(2-oxoethyl)-4'-deoxy-6-methylcirramycin A1 |
| IUPAC Name | (14E)-9-[4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-3-ethyl-7-hydroxy-2,8,10,12,16-pentamethyl-4,17-dioxabicyclo[14.1.0]heptadec-14-ene-5,13-dione |
| Canonical SMILES | CCC1C(C2C(O2)(C=CC(=O)C(CC(C(C(C(CC(=O)O1)O)C)OC3C(C(CC(O3)C)N(C)C)O)C)C)C)C |
| InChI | InChI=1S/C30H51NO8/c1-10-24-20(6)28-30(7,39-28)12-11-22(32)16(2)13-17(3)27(19(5)23(33)15-25(34)37-24)38-29-26(35)21(31(8)9)14-18(4)36-29/h11-12,16-21,23-24,26-29,33,35H,10,13-15H2,1-9H3/b12-11+ |
| InChI Key | NMAABBNXENXPAD-VAWYXSNFSA-N |
Properties
| Antibiotic Activity Spectrum | Gram-positive bacteria; Gram-negative bacteria |
| Boiling Point | 693.9°C at 760 mmHg |
| Density | 1.14 g/cm3 |
Reference Reading
1. Studies on juvenimicin, a new antibiotic. II. Isolation, chemical characterization and structures
T Kishi, S Harada, H Yamana, A Miyake J Antibiot (Tokyo). 1976 Nov;29(11):1171-81. doi: 10.7164/antibiotics.29.1171.
A series of new macrolide antibiotics was isolated from the culture filtrate of Micromonospora chalcea var, izumensis. The fat-soluble basic complex consisted of eight components which were named juvenimicin A1 approximately A4 and B1 approximately B4. Juvenimicin A3 was found to be identical with rosamicin and the structures of four of the other components (JVM A2, A4, B1 and B3) have been elucidated. Juvenimicin A2 has a methyl group at position 6 instead of the formylmethyl group of juvenimicin A3. Juvenimicin A4, B1 and B3 possess a hydroxyethyl group at position 6. Juvenimicin A4 and B1 differ from each other in the nature of the chromophore. Juvenimicin B3 differs from juvenimicin B1 in that a hydroxymethyl group is present at position 14 in the former.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
