K1115 B2
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| Category | Enzyme inhibitors |
| Catalog number | BBF-03602 |
| CAS | |
| Molecular Weight | 446.45 |
| Molecular Formula | C23H26O9 |
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Description
It is a co-produced compound of K-1115A produced by the strain of Streptomyces griseorubiginosus Mer-K1115. K1115 B2 inhibited the direct binding of activator protein-1 (AP-1) to AP-1 oligonucleotide, and the production of collagenase in IL-1 alpha-stimulated rat synovial cells.
Specification
| IUPAC Name | 10-hydroxy-8-[5-hydroxy-4-(hydroxymethyl)-1,3-dioxan-2-yl]-7-methoxy-3-methyl-1-propyl-1H-benzo[g]isochromene-6,9-dione |
| Canonical SMILES | CCCC1C2=C(C3=C(C=C2C=C(O1)C)C(=O)C(=C(C3=O)C4OCC(C(O4)CO)O)OC)O |
| InChI | InChI=1S/C23H26O9/c1-4-5-14-16-11(6-10(2)31-14)7-12-17(20(16)27)21(28)18(22(29-3)19(12)26)23-30-9-13(25)15(8-24)32-23/h6-7,13-15,23-25,27H,4-5,8-9H2,1-3H3 |
| InChI Key | OVYINHDUCFPXIJ-UHFFFAOYSA-N |
Properties
| Appearance | Red Powder |
| Boiling Point | 699.8±55.0°C at 760 mmHg |
| Melting Point | 65-67°C |
| Density | 1.4±0.1 g/cm3 |
Reference Reading
1. K1115 A, a new anthraquinone that inhibits the binding of activator protein-1 (AP-1) to its recognition sites. II. Taxonomy, fermentation, isolation, physico-chemical properties and structure determination
N Naruse, M Goto, Y Watanabe, T Terasawa, K Dobashi J Antibiot (Tokyo). 1998 Jun;51(6):545-52. doi: 10.7164/antibiotics.51.545.
A new inhibitor of the action of activator protein-1 (AP-1), designated K1115 A, was isolated from the fermentation broth of an actinomycete strain Mer-K1115. K1115 A was determined to be a new anthraquinone, 3,8-dihydroxy-1-propylanthraquinone-2-carboxylic acid, based on spectroscopic analysis, derivatization experiments and biosynthetic studies with 13C-enriched acetic acid. Two co-produced compounds, K1115 B1 and B2, were also isolated and characterized as new members of the naphthopyranomycin and exfoliamycin group.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
