Kanamycin acid disulfate
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| Category | Antibiotics |
| Catalog number | BBF-04164 |
| CAS | 64013-70-3 |
| Molecular Weight | 680.65 |
| Molecular Formula | C18H40N4O19S2 |
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Description
Kanamycin acid sulfate is an aminoglycoside antibiotic produced by Streptomyces.
Specification
| Synonyms | Kanamycin A disulfate |
| Storage | Store at 2-8°C |
| IUPAC Name | (2R,3S,4S,5R,6R)-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-4,6-diamino-3-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxyoxane-3,4,5-triol;sulfuric acid |
| Canonical SMILES | C1C(C(C(C(C1N)OC2C(C(C(C(O2)CN)O)O)O)O)OC3C(C(C(C(O3)CO)O)N)O)N.OS(=O)(=O)O.OS(=O)(=O)O |
| InChI | InChI=1S/C18H36N4O11.2H2O4S/c19-2-6-10(25)12(27)13(28)18(30-6)33-16-5(21)1-4(20)15(14(16)29)32-17-11(26)8(22)9(24)7(3-23)31-17;2*1-5(2,3)4/h4-18,23-29H,1-3,19-22H2;2*(H2,1,2,3,4)/t4-,5+,6-,7-,8+,9-,10-,11-,12+,13-,14-,15+,16-,17-,18-;;/m1./s1 |
| InChI Key | OGTKIXVMLDAMNU-KNQICTBBSA-N |
| Source | Streptomyces Kanamyceticus |
Properties
| Appearance | White to Off-white Solid |
| Antibiotic Activity Spectrum | Gram-negative bacteria; Gram-positive bacteria; mycobacteria; mycoplasma |
| Solubility | Soluble in Water |
Reference Reading
1. Optimized Extraction of Amikacin from Murine Whole Blood
Stefano Perito, Laura Mercolini, Roccaldo Sardella, Federica Ianni, Styliani Xiroudaki, Claudia Monari, Anna Vecchiarelli, Stefano Giovagnoli, Samuele Sabbatini Molecules . 2021 Jan 27;26(3):665. doi: 10.3390/molecules26030665.
Amikacin (Amk) analysis and quantitation, for pharmacokinetics studies and other types of investigations, is conventionally performed after extraction from plasma. No report exists so far regarding drug extraction from whole blood (WB). This can represent an issue since quantification in plasma does not account for drug partitioning to the blood cell compartment, significantly underrating the drug fraction reaching the blood circulation. In the present work, the optimization of an extraction method of Amk from murine WB has been described. The extraction yield was measured by RP-HPLC-UV after derivatization with 1-fluoro-2,4-dinitrobenzene, which produced an appreciably stable derivative with a favorable UV/vis absorption. Several extraction conditions were tested: spiked Amk disulfate solution/acetonitrile/WB ratio; presence of organic acids and/or ammonium hydroxide and/or ammonium acetate in the extraction mixture; re-dissolution of the supernatant in water after a drying process under vacuum; treatment of the supernatant with a solution of inorganic salts. The use of 5% (by volume) of ammonium hydroxide in a hydro-organic solution with acetonitrile, allowed the almost quantitative (95%) extraction of the drug from WB.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
