KS-504d
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| Category | Enzyme inhibitors |
| Catalog number | BBF-03608 |
| CAS | 122005-23-6 |
| Molecular Weight | 403.73 |
| Molecular Formula | C7H4Cl8O2 |
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Description
It is produced by the strain of Mollisia ventosa KAC-1148. KS-504d inhibited Ca2+ and calmodulin dependent cyclic-nucleotide phosphodiesterase with an IC50 of >500 μmol/L.
Specification
| Synonyms | KS 504d; BRN 4322179; (+)-1-(Dichloromethyl)-5-(dichloromethylene)-2,2,4,4-tetrachloro-1,3-cyclopentanediol |
| IUPAC Name | 2,2,4,4-tetrachloro-1-(dichloromethyl)-5-(dichloromethylidene)cyclopentane-1,3-diol |
| Canonical SMILES | C1(C(C(=C(Cl)Cl)C(C1(Cl)Cl)(C(Cl)Cl)O)(Cl)Cl)O |
| InChI | InChI=1S/C7H4Cl8O2/c8-2(9)1-5(17,4(10)11)7(14,15)3(16)6(1,12)13/h3-4,16-17H |
| InChI Key | NRIHIELKVOSNAZ-UHFFFAOYSA-N |
Properties
| Appearance | Colorless Powder |
| Boiling Point | 505.1°C at 760 mmHg |
| Melting Point | 78-79°C |
| Density | 1.93 g/cm3 |
Reference Reading
1. KS-504 compounds, novel inhibitors of Ca2+ and calmodulin-dependent cyclic nucleotide phosphodiesterase from Mollisia ventosa
S Nakanishi, K Ando, I Kawamoto, T Yasuzawa, H Sano, H Kase J Antibiot (Tokyo). 1989 Dec;42(12):1775-83. doi: 10.7164/antibiotics.42.1775.
Novel inhibitors of Ca2+ and calmodulin-dependent cyclic nucleotide phosphodiesterase were isolated from the culture broth of a fungus, Mollisia ventosa KAC-1148. They were designated as KS-504a, KS-504b and KS-504d. A degradative product of KS-504a, called KS-504e, was also isolated and found to inhibit the enzyme. The 50% inhibitory concentration (IC50) values of KS-504a, KS-504b, KS-504d and KS-504e for bovine brain enzyme were 122, 109, greater than 500 and 139 microM, respectively.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
