KS-504e
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| Category | Enzyme inhibitors |
| Catalog number | BBF-03609 |
| CAS | 122006-32-0 |
| Molecular Weight | 367.27 |
| Molecular Formula | C7H3Cl7O2 |
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Description
It is produced by the strain of Mollisia ventosa KAC-1148. KS-504e inhibited Ca2+ and calmodulin dependent cyclic-nucleotide phosphodiesterase with an IC50 of 139 μmol/L.
Specification
| Synonyms | KS 504e; BRN 4321107; (+)-4-Hydroxy-3,3,5,5-tetrachloro-2-(trichloromethyl)-1-cyclopentene-1-carboxaldehyde; 1-Cyclopentene-1-carboxaldehyde, 3,3,5,5-tetrachloro-4-hydroxy-2-(trichloromethyl)-, (+)- |
| IUPAC Name | 3,3,5,5-tetrachloro-4-hydroxy-2-(trichloromethyl)cyclopentene-1-carbaldehyde |
| Canonical SMILES | C(=O)C1=C(C(C(C1(Cl)Cl)O)(Cl)Cl)C(Cl)(Cl)Cl |
| InChI | InChI=1S/C7H3Cl7O2/c8-5(9)2(1-15)3(7(12,13)14)6(10,11)4(5)16/h1,4,16H |
| InChI Key | DXCKXLJBDSYGTI-UHFFFAOYSA-N |
Properties
| Appearance | Colorless Flake Crystal |
| Boiling Point | 398.6±42.0°C at 760 mmHg |
| Melting Point | 89-89.5°C |
| Density | 1.9±0.1 g/cm3 |
Reference Reading
1. KS-504 compounds, novel inhibitors of Ca2+ and calmodulin-dependent cyclic nucleotide phosphodiesterase from Mollisia ventosa
S Nakanishi, K Ando, I Kawamoto, T Yasuzawa, H Sano, H Kase J Antibiot (Tokyo). 1989 Dec;42(12):1775-83. doi: 10.7164/antibiotics.42.1775.
Novel inhibitors of Ca2+ and calmodulin-dependent cyclic nucleotide phosphodiesterase were isolated from the culture broth of a fungus, Mollisia ventosa KAC-1148. They were designated as KS-504a, KS-504b and KS-504d. A degradative product of KS-504a, called KS-504e, was also isolated and found to inhibit the enzyme. The 50% inhibitory concentration (IC50) values of KS-504a, KS-504b, KS-504d and KS-504e for bovine brain enzyme were 122, 109, greater than 500 and 139 microM, respectively.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
