Kynapcin-13
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| Category | Enzyme inhibitors |
| Catalog number | BBF-02221 |
| CAS | |
| Molecular Weight | 266.20 |
| Molecular Formula | C12H10O7 |
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Description
It is produced by the strain of Polyozellus multiplex. It can non-competitively inhibit the activity of PEP with IC50 of 76.80 μmol/L. It has a little inhibitory effect on other serine proteases.
Specification
| Synonyms | kynapcin 13 |
| IUPAC Name | dimethyl 5,6-dihydroxy-1-benzofuran-2,3-dicarboxylate |
| Canonical SMILES | COC(=O)C1=C(OC2=CC(=C(C=C21)O)O)C(=O)OC |
| InChI | InChI=1S/C12H10O7/c1-17-11(15)9-5-3-6(13)7(14)4-8(5)19-10(9)12(16)18-2/h3-4,13-14H,1-2H3 |
| InChI Key | CGSINLRWTHVPKP-UHFFFAOYSA-N |
Properties
| Appearance | Brown Powder |
| Melting Point | 186°C |
| Solubility | Soluble in Methanol |
Reference Reading
1. kynapcin-13 and -28, new benzofuran prolyl endopeptidase inhibitors from polyozellus multiplex
Sang-In Kim, In-Hye Park, Kyung-Sik Song J Antibiot (Tokyo). 2002 Jul;55(7):623-8. doi: 10.7164/antibiotics.55.623.
Two new benzofurans, 5,6-dihydroxybenzofuran-2,3-dicarboxylic acid dimethyl ester (kynapcin-13) and 5,6,5',6'-tetrahydroxy[3,3']bibenzofuranyl-2,2'-dicarboxylic acid 2'-methyl ester (kynapcin-28) were isolated from Polyozellus multiplex, and shown to non-competitively inhibit prolyl endopeptidase (PEP), with the IC50 values of 76.80 and 0.98 microM, respectively. Kynapcin-13 and -28 were less inhibitory to other serine proteases such as chymotrypsin, trypsin, and elastase.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
