LA-1

LA-1

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Category Antibiotics
Catalog number BBF-03616
CAS 61947-93-1
Molecular Weight 178.18
Molecular Formula C10H10O3

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Description

LA-1 is an aliphatic unsaturated ketonic acid produced by Streptomyces kitasatoensis NU-4-4-2. It has anti-gram-positive bacteria activity.

Specification

IUPAC Name (2E,7E)-9-oxodeca-2,5,7-trienoate
Canonical SMILES CC(=O)C=CC=C[CH+]C=CC(=O)[O-]
InChI InChI=1S/C10H10O3/c1-9(11)7-5-3-2-4-6-8-10(12)13/h2-8H,1H3/b3-2?,7-5+,8-6+
InChI Key RWIJHDVNVFLSFB-OBMXKTCTSA-N

Properties

Antibiotic Activity Spectrum Gram-positive bacteria
Boiling Point 380.1±12.0°C at 760 mmHg
Density 1.1±0.1 g/cm3

Reference Reading

1. Lactobacillus (LA-1) and butyrate inhibit osteoarthritis by controlling autophagy and inflammatory cell death of chondrocytes
Keun-Hyung Cho, Hyun Sik Na, JooYeon Jhun, Jin Seok Woo, A Ram Lee, Seung Yoon Lee, Jeong Su Lee, In Gyu Um, Seok Jung Kim, Sung-Hwan Park, Mi-La Cho Front Immunol. 2022 Oct 17;13:930511. doi: 10.3389/fimmu.2022.930511. eCollection 2022.
Osteoarthritis (OA) reduces the quality of life as a result of the pain caused by continuous joint destruction. Inactivated Lactobacillus (LA-1) ameliorated osteoarthritis and protected cartilage by modulating inflammation. In this study, we evaluated the mechanism by which live LA-1 ameliorated OA. To investigate the effect of live LA-1 on OA progression, we administered LA-1 into monosodium iodoacetate (MIA)-induced OA animals. The pain threshold, cartilage damage, and inflammation of the joint synovial membrane were improved by live LA-1. Furthermore, the analysis of intestinal tissues and feces in the disease model has been shown to affect the systems of the intestinal system and improve the microbiome environment. Interestingly, inflammation of the intestinal tissue was reduced, and the intestinal microbiome was altered by live LA-1. Live LA-1 administration led to an increase in the level of Faecalibacterium which is a short-chain fatty acid (SCFA) butyrate-producing bacteria. The daily supply of butyrate, a bacterial SCFA, showed a tendency to decrease necroptosis, a type of abnormal cell death, by inducing autophagy and reversing impaired autophagy by the inflammatory environment. These results suggest that OA is modulated by changes in the gut microbiome, suggesting that activation of autophagy can reduce aberrant cell death. In summary, live LA-1 or butyrate ameliorates OA progression by modulating the gut environment and autophagic flux. Our findings suggest the regulation of the gut microenvironment as a therapeutic target for OA.
2. Centrifugal Atomization of Glass-Forming Alloy Al86Ni8Y4.5La1.5
Jordi Pijuan, Sasha Alejandra Cegarra, Sergi Dosta, Vicente Albaladejo-Fuentes, María Dolores Riera Materials (Basel). 2022 Nov 17;15(22):8159. doi: 10.3390/ma15228159.
Centrifugal atomization is a rapid solidification technique for producing metal powders. However, its wide application has been limited to the production of common metal powders and their corresponding alloys. Therefore, there is a lack of research on the production of novel materials such as metallic glasses using this technology. In this paper, aluminum-based glassy powders (Al86Ni8Y4.5La1.5) were produced by centrifugal atomization. The effects of disk speed, atomization gas, and particle size on the cooling rate and the final microstructure of the resulting powder were investigated. The powders were characterized using SEM and XRD, and the amorphous fractions of the atomized powder samples were quantified through DSC analysis. A theoretical model was developed to evaluate the thermal evolution of the atomized droplets and to calculate their cooling rate. The average cooling rate experienced by the centrifugally atomized powder was calculated to be approximately 7 × 105 Ks-1 for particle sizes of 32.5 μm atomized at 40,000 rpm in a helium atmosphere. Amorphous fractions from 60% to 70% were obtained in particles with sizes of up to 125 μm in the most favorable atomization conditions.
3. Perovskite La1- xKxCoO3- δ (0 ≤ x ≤ 0.5): a novel bifunctional OER/ORR electrocatalyst and supercapacitive charge storage electrode in a neutral Na2SO4 electrolyte
Rakesh Mondal, Neeraj Kumar Mishra, Mahatim Singh, Asha Gupta, Preetam Singh Phys Chem Chem Phys. 2022 Nov 30;24(46):28584-28598. doi: 10.1039/d2cp04708j.
The as-prepared La1-xKxCoO3-δ (0 ≤ x ≤ 0.5) showed superior pseudocapacitive charge storage capacity in a neutral 0.5 M Na2SO4 electrolyte and superior electrocatalytic activities for the oxygen evolution reaction (OER) and oxygen reduction reaction (ORR) in a 1 M KOH electrolyte. 30% K doped p-type La0.7K0.3CoO3-δ presents superior OER activity with an overpotential of ~335 mV at 10 mA cm-2 current rate in a 1 M KOH electrolyte. Additionally, La1-xKxCoO3-δ (0 ≤ x ≤ 0.5) presents an excellent charge-storage capacitance in a neutral 0.5 M Na2SO4 electrolyte resulting in a gravimetric capacitance of the La0.5K0.5CoO3-δ electrode equivalent to 378 F g-1, 282 F g-1, 221 F g-1, 163 F g-1, and 74 F g-1 at a current density of 1 A g-1, 2 A g-1, 3 A g-1, 5 A g-1, and 10 A g-1, respectively. After 2500 continuous cycles of charge/discharge, the La0.5K0.5CoO3-δ//AC cell exhibits higher stability, capacitive retention (94%) and coulombic efficiency (97%). The gravimetric charge storage capacity of ASCs (La0.5K0.5CoO3-δ//AC) in the full cell mode showed capacitance equivalent to 308 F g-1, 287 F g-1, 238 F g-1, 209 F g-1 and 162 F g-1 at current densities of 1 A g-1, 2 A g-1, 3 A g-1, 5 A g-1 and 10 A g-1 in a neutral 0.5 M Na2SO4 electrolyte respectively. Maximum specific power equivalent to ~6884 W kg-1 was observed at a current density of 10 A g-1 when the specific energy reached ~57 W h kg-1 for the full cell. The double exchange mechanism coupled with stoichiometric oxygen defects present in the perovskite lattice seems to be operative behind the enhanced electrocatalytic OER properties, and additionally, it improves the charge storage kinetics of the La1-xKxCoO3-δ (0 ≤ x ≤ 0.5) electrode in a neutral Na2SO4 electrolyte for supercapacitor application. This work presents a rational strategy for introducing facile oxygen ion defects into perovskite structured La1-xKxCoO3-δ (0 ≤ x ≤ 0.5) to develop multifunctional electrode materials for a supercapacitor and energy conversion (OER/ORR) electrode of metal-air batteries.

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