Lactoquinomycin B
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
| Category | Antibiotics |
| Catalog number | BBF-02230 |
| CAS | 101342-94-3 |
| Molecular Weight | 473.48 |
| Molecular Formula | C24H27NO9 |
Online Inquiry
Description
It is produced by the strain of Str. tanashiensis IM 8442T. It's a quinone antibiotic. It has the activity of anti-gram-positive bacteria and some gram-negative bacteria, but the effect of anti-gram-negative bacteria is weak and has no effect on fungi. Lactoquinomycin A has stronger antibacterial activity than Lactoquinomycin B. It inhibits a variety of cell lines including lymphoma L5178Y progenitor, adriamycin resistant, bleomycin-resistant, human leukemia K562, mouse leukemia L-1210 and mouse leukemia P 388 with ID50 (μg/mL) of 0.43, 0.21, 0.19, 0.16, 0.2 and 0.12, respectively.
Specification
| Synonyms | 3a,11b-Dihydro-7-hydroxy-5-methyl-8-[2,3,6-trideoxy-3-(dimethylamino)-β-D-arabino-hexopyranosyl]-5a,11a-epoxy-5H-furo[3,2-b]naphtho[2,3-d]pyran-2,6,11(3H)-trione; 5a,11a-Epoxy-5H-furo[3,2-b]naphtho[2,3-d]pyran-2,6,11(3H)-trione, 3a,11b-dihydro-7-hydroxy-5-methyl-8-[2,3,6-trideoxy-3-(dimethylamino)-b-D-arabino-hexopyranosyl]- |
| IUPAC Name | 5-[(2R,4R,5S,6R)-4-(dimethylamino)-5-hydroxy-6-methyloxan-2-yl]-4-hydroxy-17-methyl-12,16,18-trioxapentacyclo[8.7.1.01,10.03,8.011,15]octadeca-3(8),4,6-triene-2,9,13-trione |
| Canonical SMILES | CC1C(C(CC(O1)C2=C(C3=C(C=C2)C(=O)C45C6C(CC(=O)O6)OC(C4(C3=O)O5)C)O)N(C)C)O |
| InChI | InChI=1S/C24H27NO9/c1-9-18(27)13(25(3)4)7-14(31-9)11-5-6-12-17(19(11)28)21(30)23-10(2)32-15-8-16(26)33-22(15)24(23,34-23)20(12)29/h5-6,9-10,13-15,18,22,27-28H,7-8H2,1-4H3/t9-,10?,13-,14-,15?,18-,22?,23?,24?/m1/s1 |
| InChI Key | UKGUMAYTBDAONQ-FZQVSEIZSA-N |
Properties
| Appearance | Light Yellow Crystalline Powder |
| Antibiotic Activity Spectrum | Gram-positive bacteria; Gram-negative bacteria; Neoplastics (Tumor) |
| Boiling Point | 736.8°C at 760 mmHg |
| Melting Point | 149-152°C (dec.) |
| Density | 1.52 g/cm3 |
| Solubility | Soluble in Methanol, Chloroform |
Reference Reading
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
