Lanopylin B1
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| Category | Enzyme inhibitors |
| Catalog number | BBF-02236 |
| CAS | |
| Molecular Weight | 319.57 |
| Molecular Formula | C22H41N |
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Description
It is produced by the strain of Streptomyces sp. K99-5041. It can inhibit recombinant human lanosterol synthase (EC 5.4.99.7) with IC50 of 33 μmol/L.
Specification
| Synonyms | 2-Methyl-3-[(E)-heptadecane-1-ylidene]-4,5-dihydro-3H-pyrrole |
| IUPAC Name | (4E)-4-heptadecylidene-5-methyl-2,3-dihydropyrrole |
| Canonical SMILES | CCCCCCCCCCCCCCCCC=C1CCN=C1C |
| InChI | InChI=1S/C22H41N/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-22-19-20-23-21(22)2/h18H,3-17,19-20H2,1-2H3/b22-18+ |
| InChI Key | YTIMJDBYTSJTGL-RELWKKBWSA-N |
Properties
| Appearance | Colorless Oily Matter |
| Solubility | Soluble in Methanol |
Reference Reading
1. Synthesis of lanopylin B1
Barry B Snider, Jingye Zhou J Org Chem. 2005 Feb 4;70(3):1087-8. doi: 10.1021/jo048131w.
Phase-transfer alkylation of diethyl 2-oxopropylphosphonate (9) with 2-iodoalkyl azide afforded 40% of azido phosphonate 6, which underwent a phase-transfer Horner-Emmons Wittig reaction with heptadecanal to provide 80% of azido enone 5. An intramolecular aza-Wittig reaction with polymer-bound Ph(3)P in toluene at reflux completed the first synthesis of lanopylin B(1) in 76% yield.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
