Leucinostatin B
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Category | Antibiotics |
Catalog number | BBF-02252 |
CAS | 76663-52-0 |
Molecular Weight | 1204.58 |
Molecular Formula | C61H109N11O13 |
Purity | >95% |
Online Inquiry
Description
It is produced by the strain of Paecilomyces lilacinus A-267. It's a peptide antibiotic. It has a strong anti-pathogenic and non-pathogenic yeast and fungi activity, but also has a medium anti-bacterial effect. It was previously reported that Leucinostatin A and B mixtures inhibited HeLa cells. 0.05 μg/mL of Leucinostatin B for a week (0.25 mg/kg・d) has inhibitory effect on the airy ascites carcinoma entity type, and for ascites type is invalid.
Specification
Related CAS | 88929-99-1 (hydrochloride) |
Synonyms | Paecilotoxin B; Leucinostatin A, 9-[N-[1-methyl-2-(methylamino)ethyl]-b-alaninamide]-, [9(S)]-; Antibiotic 1907-II; b-Alaninamide, cis-4-methyl-1-(4-methyl-1-oxo-2-hexenyl)-L-prolyl-(4S,6S)-6-hydroxy-4-methyl-8-oxo-L-2-aminodecanoyl-threo-3-hydroxy-L-leucyl-2-methylalanyl-L-leucyl-L-leucyl-2-methylalanyl-2-methylalanyl-N-[1-methyl-2-(methylamino)ethyl]-, [1[S-(E)],9(S)]- |
IUPAC Name | (2S,4S)-N-[(2R,4S,6S)-6-hydroxy-1-[[(2S,3R)-3-hydroxy-4-methyl-1-[[2-methyl-1-[[(2S)-4-methyl-1-[[(2S)-4-methyl-1-[[2-methyl-1-[[2-methyl-1-[[3-[[(2S)-1-(methylamino)propan-2-yl]amino]-3-oxopropyl]amino]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxopentan-2-yl]amino]-4-methyl-1,8-dioxodecan-2-yl]-4-methyl-1-[(E,4R)-4-methylhex-2-enoyl]pyrrolidine-2-carboxamide |
Canonical SMILES | CCC(C)C=CC(=O)N1CC(CC1C(=O)NC(CC(C)CC(CC(=O)CC)O)C(=O)NC(C(C(C)C)O)C(=O)NC(C)(C)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)NC(C)(C)C(=O)NC(C)(C)C(=O)NCCC(=O)NC(C)CNC)C |
InChI | InChI=1S/C61H109N11O13/c1-20-37(9)22-23-48(76)72-33-39(11)30-46(72)54(81)66-45(29-38(10)28-42(74)31-41(73)21-2)52(79)68-49(50(77)36(7)8)55(82)70-60(15,16)57(84)67-43(26-34(3)4)51(78)65-44(27-35(5)6)53(80)69-61(17,18)58(85)71-59(13,14)56(83)63-25-24-47(75)64-40(12)32-62-19/h22-23,34-40,42-46,49-50,62,74,77H,20-21,24-33H2,1-19H3,(H,63,83)(H,64,75)(H,65,78)(H,66,81)(H,67,84)(H,68,79)(H,69,80)(H,70,82)(H,71,85)/b23-22+/t37-,38-,39+,40+,42+,43+,44+,45-,46+,49+,50-/m1/s1 |
InChI Key | JLDCSWRYRVBFRU-YHHRVAAASA-N |
Properties
Appearance | Amorphous Powder |
Antibiotic Activity Spectrum | Neoplastics (Tumor); Fungi; Yeast |
Boiling Point | 1414.2°C at 760 mmHg |
Melting Point | 132-140°C |
Density | 1.119 g/cm3 |
Solubility | Soluble in Methanol, Ethanol |
Reference Reading
Recommended Products
BBF-04621 | Artemisinin | Inquiry |
BBF-04736 | 3-Indolepropionic acid | Inquiry |
BBF-00968 | Homoalanosine | Inquiry |
BBF-03427 | Tubercidin | Inquiry |
BBF-03915 | Clavulanate Potassium (1:1 mixture with silicon dioxide) | Inquiry |
BBF-01851 | Fumagillin | Inquiry |
Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2