Leucomentin-5
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
| Category | Enzyme inhibitors |
| Catalog number | BBF-02256 |
| CAS | |
| Molecular Weight | 698.67 |
| Molecular Formula | C38H34O13 |
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Description
It is produced by the strain of Paxillus panuoides. It is a free radical scavenger. It has strong inhibitory effect of lipid peroxidation with IC50 of 0.11 μg/mL. The IC50 of reference Leucomentin-2 is 0.06 μg/mL.
Specification
| IUPAC Name | [2-acetyloxy-3,6-bis(4-hydroxyphenyl)-4,5-bis[[(Z)-3-[(2R,3S)-3-methyloxiran-2-yl]prop-2-enoyl]oxy]phenyl] (Z)-3-[(2R,3S)-3-methyloxiran-2-yl]prop-2-enoate |
| Canonical SMILES | CC1C(O1)C=CC(=O)OC2=C(C(=C(C(=C2OC(=O)C)C3=CC=C(C=C3)O)OC(=O)C=CC4C(O4)C)OC(=O)C=CC5C(O5)C)C6=CC=C(C=C6)O |
| InChI | InChI=1S/C38H34O13/c1-19-27(45-19)13-16-30(42)49-36-34(24-7-11-26(41)12-8-24)38(51-32(44)18-15-29-21(3)47-29)37(50-31(43)17-14-28-20(2)46-28)33(35(36)48-22(4)39)23-5-9-25(40)10-6-23/h5-21,27-29,40-41H,1-4H3/b16-13-,17-14-,18-15-/t19-,20-,21-,27+,28+,29+/m0/s1 |
| InChI Key | QPGKQDNGSJHXHK-YQZLAJEPSA-N |
Properties
| Appearance | Gray Powder |
| Solubility | Soluble in Methanol |
Reference Reading
1. Neuroprotective activity of p-terphenyl leucomentins from the mushroom Paxillus panuoides
In-Kyoung Lee, Bong-Sik Yun, Jong-Pyung Kim, In-Ja Ryoo, Young-Ho Kim, Ick-Dong Yoo Biosci Biotechnol Biochem. 2003 Aug;67(8):1813-6. doi: 10.1271/bbb.67.1813.
The neuroprotective mechanism of p-terphenyl leucomentins from the mushroom Paxillus panuoides was studied. Leucomentins showed potent inhibition of lipid peroxidation and H2O2 neurotoxicity, but free from any role as reactive oxygen species (ROS) scavengers. Iron-mediated oxidative damage has been implicated in these processes, as a provider of ROS via iron. Leucomentins can chelate iron when DNA is present with iron and H2O2, and so inhibiting DNA single strand breakage. These results suggest that the neuroprotective action of leucomentins is dependent on their ability to chelate iron.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
